The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

LODI R, PIERANGELI G, TONON C, CEVOLI S, TESTA C, BIVONA G, et al. (2006). Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy. NEUROLOGY, 66(8), 1264-1266 [10.1212/01.wnl.0000208442.07548.71].

Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy

BIVONA, Giulia;
2006-01-01

Abstract

The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.
2006
LODI R, PIERANGELI G, TONON C, CEVOLI S, TESTA C, BIVONA G, et al. (2006). Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy. NEUROLOGY, 66(8), 1264-1266 [10.1212/01.wnl.0000208442.07548.71].
File in questo prodotto:
File Dimensione Formato  
neurology.pdf

accesso aperto

Dimensione 316.47 kB
Formato Adobe PDF
316.47 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/14018
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 58
  • ???jsp.display-item.citation.isi??? 49
social impact