The chaperoning system is the wole complement of chaperones, co-chaperones and chaperone cofactors of the body that preserves cell and tissue homeostasis. Its structural and/or functional defects can cause pathologic conditions, nemed chaperonopathies. Large bowel homeostasis includes a healthy status of the mucosal tissues and the microbiota. An alteration of one of them may determine, in turn, modifications of the other. Molecular chaperones of bacteria and human origin have been implicated in inflammatory bowel disease (IBD). In IBD chaperone levels usually increase and their cellular and subcellular loclization change. This is considered a physiological stress-response of mucosal cells to inflammation. However, chaperones also play active roles in IBD pathogenesis, e.g. perpetuate inflammation. Therefore, IBD can be classified among the chaperonopathies. This classification opens the door to the design and application of new forms of treatment targeting the chaperones, namely chaperonopathy.

Cappello, F., Tomasello, G., Rappa, F., Farina, F., Zummo, G., De Macario, E.C., et al. (2015). ROLE OF CHAPERONES IN HEALTHY BOWEL AND IBD.. In Experimental Biology 2015 meeting in Boston. The meeting was held at the Boston Convention and Exhibition Center from March 28 to April 1, 2015. -http://www.aspet.org/EB2015/ (pp.350-352). Boston.

ROLE OF CHAPERONES IN HEALTHY BOWEL AND IBD.

CAPPELLO, Francesco;TOMASELLO, Giovanni;RAPPA, Francesca;FARINA, Felicia;ZUMMO, Giovanni;
2015-01-01

Abstract

The chaperoning system is the wole complement of chaperones, co-chaperones and chaperone cofactors of the body that preserves cell and tissue homeostasis. Its structural and/or functional defects can cause pathologic conditions, nemed chaperonopathies. Large bowel homeostasis includes a healthy status of the mucosal tissues and the microbiota. An alteration of one of them may determine, in turn, modifications of the other. Molecular chaperones of bacteria and human origin have been implicated in inflammatory bowel disease (IBD). In IBD chaperone levels usually increase and their cellular and subcellular loclization change. This is considered a physiological stress-response of mucosal cells to inflammation. However, chaperones also play active roles in IBD pathogenesis, e.g. perpetuate inflammation. Therefore, IBD can be classified among the chaperonopathies. This classification opens the door to the design and application of new forms of treatment targeting the chaperones, namely chaperonopathy.
Settore MED/12 - Gastroenterologia
Settore BIO/06 - Anatomia Comparata E Citologia
2015
EXPERIMENTAL BIOLOGY 2015
BOSTON - USA
28 MARZO-1 APRILE 2015
SESSION 7003
3
Online
Experimental Biology 2015 meeting in Boston. The meeting was held at the Boston Convention and Exhibition Center from March 28 to April 1, 2015.
Cappello, F., Tomasello, G., Rappa, F., Farina, F., Zummo, G., De Macario, E.C., et al. (2015). ROLE OF CHAPERONES IN HEALTHY BOWEL AND IBD.. In Experimental Biology 2015 meeting in Boston. The meeting was held at the Boston Convention and Exhibition Center from March 28 to April 1, 2015. -http://www.aspet.org/EB2015/ (pp.350-352). Boston.
Proceedings (atti dei congressi)
Cappello,F; Tomasello,G; Rappa,F; Farina,F; Zummo,G; De Macario,EC; Macario,JLA
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/130934
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