Purpose: The aim of the present study was to assess the long-term tolerability and efficacy of intranasal fentanyl (INFS) in opioid-tolerant patients with breakthrough cancer pain (BTP).Patients and methods: A 6 months, observational, prospective, cohort study design was employed to follow advanced cancer patients with BTP receiving INFS under routine clinical practice. Eligible adult cancer patients suffering from BTP had been prescribed INFS at effective doses. Data were collected at T0 and at month intervals for six months. The principal outcomes were the evaluation of possible serious adverse effects with prolonged use of INFS, the efficacy of BTP treatment with INFS, the quality of sleep, the rate of INFS discontinuation, and reasons for that.Results: Seventy-five patients were surveyed. Thirty-four patients (45.3 %) had a follow-up at 3 months, and twelve patients (16 %) were followed up at 6 months. The mean opioid doses, expressed as oral morphine equivalents, ranged 111–180 mg/day, while the mean INFS doses were 87–119 μg. Adverse effects were reported in a minority of patients and were considered to be associated with opioid therapy used for background pain. The quality of sleep significantly improved during the first 3–4 months. Finally, efficacy based on a general impression regarding the efficacy of INFS was good-excellent in most patients and statistically improved in time up to the third month.Conclusion: The long-term use of INFS in advanced cancer patients is effective and safe. No serious adverse effects were found up to six months of assessment. The level of quality of sleep and patients’ satisfaction was relatively good, considering the advanced stage of disease.

Mercadante, S., Vellucci, R., Cuomo, A., Adile, C., Cortegiani, A., Valle, A., et al. (2015). Long-term efficacy and tolerability of intranasal fentanyl in the treatment of breakthrough cancer pain. SUPPORTIVE CARE IN CANCER, 23(5), 1349-1354 [10.1007/s00520-014-2491-x].

Long-term efficacy and tolerability of intranasal fentanyl in the treatment of breakthrough cancer pain

CORTEGIANI, Andrea;CASUCCIO, Alessandra
2015-01-01

Abstract

Purpose: The aim of the present study was to assess the long-term tolerability and efficacy of intranasal fentanyl (INFS) in opioid-tolerant patients with breakthrough cancer pain (BTP).Patients and methods: A 6 months, observational, prospective, cohort study design was employed to follow advanced cancer patients with BTP receiving INFS under routine clinical practice. Eligible adult cancer patients suffering from BTP had been prescribed INFS at effective doses. Data were collected at T0 and at month intervals for six months. The principal outcomes were the evaluation of possible serious adverse effects with prolonged use of INFS, the efficacy of BTP treatment with INFS, the quality of sleep, the rate of INFS discontinuation, and reasons for that.Results: Seventy-five patients were surveyed. Thirty-four patients (45.3 %) had a follow-up at 3 months, and twelve patients (16 %) were followed up at 6 months. The mean opioid doses, expressed as oral morphine equivalents, ranged 111–180 mg/day, while the mean INFS doses were 87–119 μg. Adverse effects were reported in a minority of patients and were considered to be associated with opioid therapy used for background pain. The quality of sleep significantly improved during the first 3–4 months. Finally, efficacy based on a general impression regarding the efficacy of INFS was good-excellent in most patients and statistically improved in time up to the third month.Conclusion: The long-term use of INFS in advanced cancer patients is effective and safe. No serious adverse effects were found up to six months of assessment. The level of quality of sleep and patients’ satisfaction was relatively good, considering the advanced stage of disease.
2015
Settore MED/42 - Igiene Generale E Applicata
Mercadante, S., Vellucci, R., Cuomo, A., Adile, C., Cortegiani, A., Valle, A., et al. (2015). Long-term efficacy and tolerability of intranasal fentanyl in the treatment of breakthrough cancer pain. SUPPORTIVE CARE IN CANCER, 23(5), 1349-1354 [10.1007/s00520-014-2491-x].
File in questo prodotto:
File Dimensione Formato  
art%3A10.1007%2Fs00520-014-2491-x.pdf

accesso aperto

Descrizione: articolo principale
Dimensione 149.46 kB
Formato Adobe PDF
149.46 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/129635
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 19
social impact