Aim. In the present study, 18Fluoro-2-deoxy-D-Glucose-Positron Emission Tomography (FDG-PET) findings were compared with histopathological results of sentinel lymph-node biopsy (SNLB). The purpose was to determine the value of FDG-PET in predicting regional lymph-node involvement in patients with primary melanoma stage I and II. Methods. Twenty five consecutive patients with primary cutaneous melanoma, stage I and II, underwent FDG-PET scans, preoperative lymphoscintigraphy, and SNLB. The sentinel node detection was sistematically performed within the week following the PET scanning. Results. The FDG-PET and SNLB results were interpreted independently of each other and then compared. Conclusions. SNLB remains the technique of choise for evaluating the histological status of lymph-node basins and is the only reliable method for identifying micrometastatic disease in the regional draining node; FDG-PET appears insufficiently sensitive to identify microscopic nodal metastases and cannnot be expected to give additional information of stage I-II patients. Based on our results and data from literature, the Authors not recommend 18-FDG-PET as a first line imaging strategy for staging with a AJCC stage I or II primary disease.

CORDOVA A, NAPOLI P, COSTA R, GIAMBONA C, TRIPOLI M, MOSCHELLA F (2006). 18Fluoro2deoxy-Dglucose-Positron Emission Tomography (FDG-PET) Imaging versus sentinel lymph node biopsy (SLNB) in the staging of cutaneous melanoma in AJCC stage i and II. CHIRURGIA, 19, 189-192.

18Fluoro2deoxy-Dglucose-Positron Emission Tomography (FDG-PET) Imaging versus sentinel lymph node biopsy (SLNB) in the staging of cutaneous melanoma in AJCC stage i and II.

CORDOVA, Adriana;GIAMBONA, Cristiano;MOSCHELLA, Francesco
2006-01-01

Abstract

Aim. In the present study, 18Fluoro-2-deoxy-D-Glucose-Positron Emission Tomography (FDG-PET) findings were compared with histopathological results of sentinel lymph-node biopsy (SNLB). The purpose was to determine the value of FDG-PET in predicting regional lymph-node involvement in patients with primary melanoma stage I and II. Methods. Twenty five consecutive patients with primary cutaneous melanoma, stage I and II, underwent FDG-PET scans, preoperative lymphoscintigraphy, and SNLB. The sentinel node detection was sistematically performed within the week following the PET scanning. Results. The FDG-PET and SNLB results were interpreted independently of each other and then compared. Conclusions. SNLB remains the technique of choise for evaluating the histological status of lymph-node basins and is the only reliable method for identifying micrometastatic disease in the regional draining node; FDG-PET appears insufficiently sensitive to identify microscopic nodal metastases and cannnot be expected to give additional information of stage I-II patients. Based on our results and data from literature, the Authors not recommend 18-FDG-PET as a first line imaging strategy for staging with a AJCC stage I or II primary disease.
2006
CORDOVA A, NAPOLI P, COSTA R, GIAMBONA C, TRIPOLI M, MOSCHELLA F (2006). 18Fluoro2deoxy-Dglucose-Positron Emission Tomography (FDG-PET) Imaging versus sentinel lymph node biopsy (SLNB) in the staging of cutaneous melanoma in AJCC stage i and II. CHIRURGIA, 19, 189-192.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/12774
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