The relationship between severity of obstructive sleep apnea (OSA) and kidney function was investigated in the European Sleep Apnea Database (ESADA), where clinical, sleep, and biochemical data of patients studied for suspected OSA in 24 sleep centres of 17 European countries are stored. After excluding patients with missing data or extremely high/low creatinine values, data from 8112 subjects (2328 female) with creatinine values ranging between 0.5 and 2.0 mg% were analyzed. Estimated glomerular filtration rate (eGFR) was obtained with the Modified Diet in Renal Disease (MDRD) equation. Patients were subdivided into two groups: group 1 (n = 3709) studied by full polysomnography; group 2 (n = 4403) studied by nocturnal cardiorespiratory monitoring. Altogether, 8.5% subjects had an eGFR<60 ml/min/1.73m2. At univariate analysis, eGFR correlated to age, comorbidities and severity of OSA in both groups. At logistic regression analysis, risk factors for eGFR<60 were in group 1: diabetes, female gender, age, body mass index, and lowest nocturnal SaO2 (r2=0.086); in group 2: hypertension, female gender, age, and lowest nocturnal SaO2 (r2=0.087). In conclusion, as expected, comorbidities, female gender and advanced age are significant risk factors for low eGFR in subjects with OSA. While traditional severity measures of OSA (apnea/hypopnea index, oxygen desaturation index) did not contribute to low eGFR, more severe nocturnal hypoxia captured by lowest nocturnal SaO2 appeared as a significant predictor in this large patient cohort. The ESADA study is supported by ResMed and Philips Respironics.
Marrone, O., Battaglia, S., Bonsignore, M. (2013). Relationship between mild to moderate renal dysfunction and obstructive sleep apnea: Data from the European sleep apnea database. In European Respiratory Society Annual Congress 2013 Abstract book (pp.P4037-P4037).
Relationship between mild to moderate renal dysfunction and obstructive sleep apnea: Data from the European sleep apnea database
BATTAGLIA, Salvatore;BONSIGNORE, Maria Rosaria
2013-01-01
Abstract
The relationship between severity of obstructive sleep apnea (OSA) and kidney function was investigated in the European Sleep Apnea Database (ESADA), where clinical, sleep, and biochemical data of patients studied for suspected OSA in 24 sleep centres of 17 European countries are stored. After excluding patients with missing data or extremely high/low creatinine values, data from 8112 subjects (2328 female) with creatinine values ranging between 0.5 and 2.0 mg% were analyzed. Estimated glomerular filtration rate (eGFR) was obtained with the Modified Diet in Renal Disease (MDRD) equation. Patients were subdivided into two groups: group 1 (n = 3709) studied by full polysomnography; group 2 (n = 4403) studied by nocturnal cardiorespiratory monitoring. Altogether, 8.5% subjects had an eGFR<60 ml/min/1.73m2. At univariate analysis, eGFR correlated to age, comorbidities and severity of OSA in both groups. At logistic regression analysis, risk factors for eGFR<60 were in group 1: diabetes, female gender, age, body mass index, and lowest nocturnal SaO2 (r2=0.086); in group 2: hypertension, female gender, age, and lowest nocturnal SaO2 (r2=0.087). In conclusion, as expected, comorbidities, female gender and advanced age are significant risk factors for low eGFR in subjects with OSA. While traditional severity measures of OSA (apnea/hypopnea index, oxygen desaturation index) did not contribute to low eGFR, more severe nocturnal hypoxia captured by lowest nocturnal SaO2 appeared as a significant predictor in this large patient cohort. The ESADA study is supported by ResMed and Philips Respironics.File | Dimensione | Formato | |
---|---|---|---|
ERS 2013 - Marrone .pdf
accesso aperto
Descrizione: articolo principale
Dimensione
120.02 kB
Formato
Adobe PDF
|
120.02 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.