Background: Human Cytomegalovirus (HCMV) infection has been reported to be a cause of refractory ulcerative colitis (UC). Toxic megacolon (TM) is a rare but severe complication of an acute attack of UC. Objectives: Aim of this study is to evaluate in a case-control study the association between HCMV and TM. Study design: All patients who were admitted at Medicine Department of V. Cervello Hospital in Palermo (tertiary referral center) for a severe UC flare-up complicated by the onset of TM (diameter of the transverse colon. >. 6. cm) between January 1990 and November 2011 were identified through the electronic database. A total of 24 consecutive patients (16 male/8 female) with TM were identified. Each case of TM were individually matched by sex, age, extent of the underlying disease to 24 severe UC controls who did not develop TM. A further non matched control population of 48 severe UC was included.Haematoxilin and eosin stain, immunohistochemical procedure and nested polymerase chai...

Criscuoli, V., Rizzuto, M., Gallo, E., Orlando, A., Cottone, M. (2015). Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. JOURNAL OF CLINICAL VIROLOGY, 66(66), 103-106 [10.1016/j.jcv.2015.03.009].

Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients

CRISCUOLI, Valeria;ORLANDO, Ambrogio;COTTONE, Mario
2015-01-01

Abstract

Background: Human Cytomegalovirus (HCMV) infection has been reported to be a cause of refractory ulcerative colitis (UC). Toxic megacolon (TM) is a rare but severe complication of an acute attack of UC. Objectives: Aim of this study is to evaluate in a case-control study the association between HCMV and TM. Study design: All patients who were admitted at Medicine Department of V. Cervello Hospital in Palermo (tertiary referral center) for a severe UC flare-up complicated by the onset of TM (diameter of the transverse colon. >. 6. cm) between January 1990 and November 2011 were identified through the electronic database. A total of 24 consecutive patients (16 male/8 female) with TM were identified. Each case of TM were individually matched by sex, age, extent of the underlying disease to 24 severe UC controls who did not develop TM. A further non matched control population of 48 severe UC was included.Haematoxilin and eosin stain, immunohistochemical procedure and nested polymerase chai...
2015
Criscuoli, V., Rizzuto, M., Gallo, E., Orlando, A., Cottone, M. (2015). Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients. JOURNAL OF CLINICAL VIROLOGY, 66(66), 103-106 [10.1016/j.jcv.2015.03.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/127422
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