Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35℃ and 45℃ and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

Caputo, G. (2013). Supercritical Fluid Adsorption of Domperidone on Silica Aerogel. ADVANCES IN CHEMICAL ENGINEERING AND SCIENCE, 3 [doi:10.4236/aces.2013.33024].

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel

CAPUTO, Giuseppe
2013-01-01

Abstract

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35℃ and 45℃ and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=34259#.VNoFuL699Gx
Caputo, G. (2013). Supercritical Fluid Adsorption of Domperidone on Silica Aerogel. ADVANCES IN CHEMICAL ENGINEERING AND SCIENCE, 3 [doi:10.4236/aces.2013.33024].
File in questo prodotto:
File Dimensione Formato  
ACES_2013071111120906.pdf

accesso aperto

Descrizione: articolo completo
Dimensione 163.62 kB
Formato Adobe PDF
163.62 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/108534
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact