One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).
Calapai, G., Imbesi, S., Ventura Spagnolo, E., Cafeo, V., Milone, L., Navarra, M., et al. (2016). FATAL ANAPHYLACTIC SHOCK CEFTRIAXONE-INDUCED IN A 4 YEAR-OLD CHILD. PEDIATRIC EMERGENCY CARE, 32(1), 32-33.
FATAL ANAPHYLACTIC SHOCK CEFTRIAXONE-INDUCED IN A 4 YEAR-OLD CHILD
VENTURA SPAGNOLO, Elvira;MILONE, Livio;
2016-01-01
Abstract
One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).
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