The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures. Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors. Metformin administration started 2 months before the ovulation induction. Alternatively a spontaneous menstruation it was induced by progestin. Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support was administrated. Results showed 100% of ovulatory cycles, 5 pregnancies and only 1 lost. Few side effects.

GULLO, G., VASSILIADIS, A., UNFER, V., CARLOMAGNO G, & CATALANO G (2014). PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data. GIORNALE ITALIANO DI OSTETRICIA E GINECOLOGIA, XXXVI(4/5), 443-447 [10.11138/giog/2014.36.4.443].

PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data.

VASSILIADIS, Alessandra;
2014

Abstract

The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures. Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors. Metformin administration started 2 months before the ovulation induction. Alternatively a spontaneous menstruation it was induced by progestin. Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support was administrated. Results showed 100% of ovulatory cycles, 5 pregnancies and only 1 lost. Few side effects.
Settore MED/40 - Ginecologia E Ostetricia
GULLO, G., VASSILIADIS, A., UNFER, V., CARLOMAGNO G, & CATALANO G (2014). PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data. GIORNALE ITALIANO DI OSTETRICIA E GINECOLOGIA, XXXVI(4/5), 443-447 [10.11138/giog/2014.36.4.443].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/103417
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