| Nome |
# |
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Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections, file e3ad8925-3833-da0e-e053-3705fe0a2b96
|
456
|
|
The future of antibiotic: From the magic bullet to the smart bullet, file e3ad8916-e728-da0e-e053-3705fe0a2b96
|
297
|
|
N-(INDAZOLYL)BENZAMIDO DERIVATIVES AS CDK1 INHIBITORS: DESIGN, SYNTHESIS, BIOLOGICAL ACTIVITY, AND MOLECULAR DOCKING STUDIES, file e3ad891b-659b-da0e-e053-3705fe0a2b96
|
265
|
|
Synthesis and antitumor activity of new thiazole nortopsentin analogs, file e3ad891a-83a9-da0e-e053-3705fe0a2b96
|
200
|
|
Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[2E]-3-phenylprop-2-enoylamino}benzamides, file e3ad8919-0095-da0e-e053-3705fe0a2b96
|
199
|
|
Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives, file e3ad8921-f6a7-da0e-e053-3705fe0a2b96
|
186
|
|
3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1HIndole derivatives as new anticancer agents in the treatment of pancreatic ductal adenocarcinoma, file e3ad8921-b7d1-da0e-e053-3705fe0a2b96
|
151
|
|
An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge, file e3ad891d-4c46-da0e-e053-3705fe0a2b96
|
148
|
|
Comparative studies of the Pschorr reaction in the pyrazole series. Access to the new dibenzo(e,g)pyrazolo(1,5-a)(1,3)diazocine system of pharmaceutical interest, file e3ad8918-0bcf-da0e-e053-3705fe0a2b96
|
138
|
|
A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (Holothuria tubulosa) in the Control of Listeria monocytogenes, file e3ad891e-b72c-da0e-e053-3705fe0a2b96
|
135
|
|
Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and related derivatives, file e3ad8919-1921-da0e-e053-3705fe0a2b96
|
131
|
|
New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity, file e3ad891e-a585-da0e-e053-3705fe0a2b96
|
118
|
|
β -Lactoglobulin Heptapeptide Reduces Oxidative Stress in Intestinal Epithelial Cells and Angiotensin II-Induced Vasoconstriction on Mouse Mesenteric Arteries by Induction of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Translocation, file e3ad8920-d521-da0e-e053-3705fe0a2b96
|
114
|
|
New Tripentone Analogs with Antiproliferative Activity, file e3ad891c-c034-da0e-e053-3705fe0a2b96
|
113
|
|
CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin, file e3ad8926-ec13-da0e-e053-3705fe0a2b96
|
104
|
|
New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation, file e3ad891f-0759-da0e-e053-3705fe0a2b96
|
101
|
|
Pharmaceutical potential of synthetic and natural pyrrolomycins, file e3ad8919-953a-da0e-e053-3705fe0a2b96
|
97
|
|
Bacterial Biofilm Inhibition in the Development of Effective Anti-Virulence Strategy, file e3ad891e-f1f2-da0e-e053-3705fe0a2b96
|
97
|
|
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum, file e3ad8927-161b-da0e-e053-3705fe0a2b96
|
74
|
|
Biofilm capability of staphylococcus strains isolated from food and the anti-biofilm activity of a chemically synthesized pyrrolomycin, file e3ad891c-f3a8-da0e-e053-3705fe0a2b96
|
68
|
|
Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells, file e3ad8923-db07-da0e-e053-3705fe0a2b96
|
65
|
|
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy, file e3ad8927-61a2-da0e-e053-3705fe0a2b96
|
63
|
|
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation, file e3ad8925-1cf2-da0e-e053-3705fe0a2b96
|
61
|
|
Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies, file e3ad8923-db06-da0e-e053-3705fe0a2b96
|
59
|
|
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells, file e3ad8927-c0a2-da0e-e053-3705fe0a2b96
|
59
|
|
Open Sesame? : Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity
in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer, file e3ad8923-f732-da0e-e053-3705fe0a2b96
|
54
|
|
Pyrrolomycins as potential anti-staphylococcal biofilms agents, file e3ad8915-c7f1-da0e-e053-3705fe0a2b96
|
53
|
|
Role of hypoxia in pemetrexed-resistance of mesothelioma mediated by proton-coupled folate transporter, and preclinical activity of new anti-LDH compounds, file e3ad891c-f52a-da0e-e053-3705fe0a2b96
|
51
|
|
NUOVI DERIVATI 2-ACETAMMIDOBENZAMMIDICI:
ATTIVITÀ ANTIPROLIFERATIVA E POSSIBILE MECCANISMO DI AZIONE, file e3ad891b-7afa-da0e-e053-3705fe0a2b96
|
46
|
|
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds, file e3ad8924-1690-da0e-e053-3705fe0a2b96
|
43
|
|
SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance, file e3ad8927-975c-da0e-e053-3705fe0a2b96
|
40
|
|
Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides, file e3ad8927-e6dd-da0e-e053-3705fe0a2b96
|
37
|
|
A peptide from human β thymosin as a platform for the development of new anti-biofilm agents for Staphylococcus spp. and Pseudomonas aeruginosa, file e3ad8921-8ffd-da0e-e053-3705fe0a2b96
|
18
|
|
Oregano essential oils activity against Listeria monocitogenes biofilms, file e3ad8918-169f-da0e-e053-3705fe0a2b96
|
17
|
|
Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives, file e3ad8916-eed9-da0e-e053-3705fe0a2b96
|
14
|
|
ATTIVITÀ ANTIPROLIFERATIVA DI UN DERIVATO POLICICLICO CON STRUTTURA COMPLESSA, file e3ad8916-f4c2-da0e-e053-3705fe0a2b96
|
12
|
|
Quality, functional and sensory evaluation of pasta fortified with extracts from Opuntia ficus-indica cladodes, file e3ad8928-1468-da0e-e053-3705fe0a2b96
|
12
|
|
Paracentrin1, a synthetic antimicrobial peptide fragment of a beta-thymosin from the sea-urchin Paracentrotus lividus, interferes whith staphylococcal and Pseudomonas aeruginosa biofilm formation, file e3ad8918-14ab-da0e-e053-3705fe0a2b96
|
10
|
|
Synthesis of alkyl-5,8-dimethyl-6-phenyl-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-ones of pharmaceutical interest, file e3ad891e-22b0-da0e-e053-3705fe0a2b96
|
10
|
|
Synthesis and antiproliferative activity of 3-(2-cloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one, file e3ad8927-ef4b-da0e-e053-3705fe0a2b96
|
10
|
|
Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound, file e3ad8916-e6f2-da0e-e053-3705fe0a2b96
|
9
|
|
Synthesis and antiproliferative activity of 3-(2-cloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one, file e3ad8917-d975-da0e-e053-3705fe0a2b96
|
9
|
|
Quality characteristics and in vitro digestibility study of barley flour enriched ditalini pasta, file e3ad8919-1f95-da0e-e053-3705fe0a2b96
|
9
|
|
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity, file e3ad891e-fc1e-da0e-e053-3705fe0a2b96
|
9
|
|
Synthesis of alkyl-5,8-dimethyl-6-phenyl-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-ones of pharmaceutical interest, file e3ad8915-9bdb-da0e-e053-3705fe0a2b96
|
8
|
|
Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality, file e3ad891c-42f6-da0e-e053-3705fe0a2b96
|
8
|
|
Quality, functional and sensory evaluation of pasta fortified with extracts from Opuntia ficus-indica cladodes, file e3ad8922-09b5-da0e-e053-3705fe0a2b96
|
8
|
|
Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle, file e3ad8917-e86b-da0e-e053-3705fe0a2b96
|
7
|
|
Sortase A Inhibitors: Recent Advances and Future Perspectives, file e3ad8919-8aaa-da0e-e053-3705fe0a2b96
|
7
|
|
Antibacterial Activity of Desert Truffles from Saudi Arabia Against Staphylococcus aureus and Pseudomonas aeruginosa, file e3ad891b-3dbb-da0e-e053-3705fe0a2b96
|
7
|
|
A peptide from human β thymosin as a platform for the development of new anti-biofilm agents for Staphylococcus spp. and Pseudomonas aeruginosa, file e3ad891b-68a5-da0e-e053-3705fe0a2b96
|
7
|
|
Biological evaluation of new 1,2,4-oxadiazole topsentin analogs as anticancer agents, file e3ad891e-a3a2-da0e-e053-3705fe0a2b96
|
7
|
|
null, file 026b6a91-0b09-498f-a37a-ace7aab682ee
|
6
|
|
A new class of phenylhydrazinylidene derivatives as inhibitors of Staphylococcus aureus biofilm formation, file e3ad8919-1924-da0e-e053-3705fe0a2b96
|
6
|
|
Synthesis and biofilm formation reduction of pyrazole-4-carboxamide derivatives in some Staphylococcus aureus strains, file e3ad8919-dda3-da0e-e053-3705fe0a2b96
|
6
|
|
An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds, file e3ad891b-e791-da0e-e053-3705fe0a2b96
|
6
|
|
1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase, file e3ad8925-14cb-da0e-e053-3705fe0a2b96
|
6
|
|
Quality characteristics and in vitro digestibility study of barley flour enriched ditalini pasta, file e3ad8928-42af-da0e-e053-3705fe0a2b96
|
6
|
|
1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation, file 0f7b513c-f3d7-4bd6-b58e-a866350cb766
|
5
|
|
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma, file a835ba4a-94cf-4912-85bc-99eaf1072438
|
5
|
|
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods, file e3ad891b-24c2-da0e-e053-3705fe0a2b96
|
5
|
|
Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues, file e3ad891b-405c-da0e-e053-3705fe0a2b96
|
5
|
|
Pyrazolobenzotriazinones Derivatives as COX Inhibitors: Synthesis Biological Activity and Molecular Modeling Studies, file e3ad891b-fca7-da0e-e053-3705fe0a2b96
|
5
|
|
Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance, file e3ad891e-a37a-da0e-e053-3705fe0a2b96
|
5
|
|
Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells*, file e3ad8920-d2f4-da0e-e053-3705fe0a2b96
|
5
|
|
Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry, file e3ad8927-941e-da0e-e053-3705fe0a2b96
|
5
|
|
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification, file e3ad8928-3102-da0e-e053-3705fe0a2b96
|
5
|
|
1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1, file b788526c-652c-4b94-8e52-a0edfa649c82
|
4
|
|
Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy, file c0c6bdbd-6632-4fe6-a25e-4550614d4b08
|
4
|
|
New Topsentin analogs as inhibitors of biofilm formation, file e3ad891e-fc69-da0e-e053-3705fe0a2b96
|
4
|
|
Synthesis and antitumor activity of new thiazole nortopsentin analogs, file e3ad8921-e257-da0e-e053-3705fe0a2b96
|
4
|
|
Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma, file 31ecfe93-cdae-4780-b102-f4bf81a1c1b8
|
3
|
|
Eight-Membered Rings With Two Heteroatoms 1,3, file 3c0e1d49-2e3f-48f2-aa63-a39c84ad2e6e
|
3
|
|
Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New?, file 7557e479-324b-4c16-8362-2415e645b869
|
3
|
|
A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation, file b028475f-e79d-47c9-9173-9859fd594a33
|
3
|
|
Paracentrin 1, a synthetic antimicrobial peptide fragment of a beta-thymosin from the sea-urchin Paracentrotus lividus, interferes with staphylococcal and Pseudomonas aeruginosa biofilm formation, file e3ad8916-fd01-da0e-e053-3705fe0a2b96
|
3
|
|
Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms, file e3ad891b-6f56-da0e-e053-3705fe0a2b96
|
3
|
|
1,3,5-Triazines: A promising scaffold for anticancer drugs development, file e3ad891b-d49f-da0e-e053-3705fe0a2b96
|
3
|
|
Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives, file e3ad891b-e322-da0e-e053-3705fe0a2b96
|
3
|
|
2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors, file e3ad891e-d678-da0e-e053-3705fe0a2b96
|
3
|
|
Pharmacogenetics of treatments for pancreatic cancer, file e3ad8920-f3fd-da0e-e053-3705fe0a2b96
|
3
|
|
Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry, file e3ad8921-b7d5-da0e-e053-3705fe0a2b96
|
3
|
|
Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance, file e3ad8923-c04a-da0e-e053-3705fe0a2b96
|
3
|
|
New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma, file e3ad8923-ce14-da0e-e053-3705fe0a2b96
|
3
|
|
1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A, file e3ad8925-4d33-da0e-e053-3705fe0a2b96
|
3
|
|
Development of a new indole derivative dry powder for inhalation for the treatment of biofilm-associated lung infections, file dca52129-f8b7-4298-8100-185ab011fd63
|
2
|
|
Synthesis of substituted 3-amino-N-phenyl-1H-indazole-1-carboxamides endowed with antiproliferative activity, file e3ad8918-faf4-da0e-e053-3705fe0a2b96
|
2
|
|
Pyrrolo[3′,2′:6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity, file e3ad891a-958b-da0e-e053-3705fe0a2b96
|
2
|
|
Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines, file e3ad891e-c5af-da0e-e053-3705fe0a2b96
|
2
|
|
Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells, file e3ad8921-f643-da0e-e053-3705fe0a2b96
|
2
|
|
Dynamic-shared pharmacophore approach as tool to design new allosteric PRC2 inhibitors, targeting EED binding pocket, file e3ad8925-47a1-da0e-e053-3705fe0a2b96
|
2
|
|
Novel strategies in the war against antibiotic resistance, file e3ad8927-9f52-da0e-e053-3705fe0a2b96
|
2
|
|
Eight-membered heterocycles with two heteroatoms in a 1,2-relationship of interest in medicinal chemistry, file e3ad8927-e959-da0e-e053-3705fe0a2b96
|
2
|
|
Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development, file 9b18cb8f-fd54-4201-a9ea-50cec1a48a4f
|
1
|
|
Eight-Membered Rings With Two Heteroatoms 1,2, file bc556031-ae08-4b67-a786-a1f109ce5f9f
|
1
|
|
In vitro anti-Gram-positive and anti-staphylococcal biofilm activity of newly halogenated pyrroles related to Pyrrolomycins, file e3ad8915-9cc0-da0e-e053-3705fe0a2b96
|
1
|
|
Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine, file e3ad8916-76d6-da0e-e053-3705fe0a2b96
|
1
|
|
Synthesis and antiproliferative activity of new derivatives containing the polycyclic system 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3’,4’:2,3]azepino[4,5-f]azocine, file e3ad8916-9e68-da0e-e053-3705fe0a2b96
|
1
|
|
Sortase A: An ideal target for anti-virulence drug development, file e3ad891b-fcbf-da0e-e053-3705fe0a2b96
|
1
|
|
Synthesis and induction of G0-G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one, file e3ad891c-8042-da0e-e053-3705fe0a2b96
|
1
|
| Totale |
4.183 |