Biocompatibility analyses showed that formulated hydrogels were not toxic and didn’t induce apoptosis. Chondrocyte were alive but not proliferative, inflammation and immune responses were observed but under certain acceptability threshold. The results of this preliminary work suggest that the formulated Chitosan hydrogels are cyto-compatible and induce chondrocyte differentiation. The here tested synthesis process generated hydrogels, which are potentially useful for cartilage regenerative processes. Further mechanical characterizations are in progress.
Saladino, S., Di Leonardo, E.R., Salamone, M., Mercuri, D., Segatti, F., Ghersi, G. (2014). Formulation of Different Chitosan Hydrogels for Cartilage Tissue Repair. In CHEMICAL ENGINEERING TRANSACTIONS VOL.38,2014 ISBN 978-88-95608-29-7; ISSN 2283-9216 (pp.505-510) [10.3303/CET1438085].
Formulation of Different Chitosan Hydrogels for Cartilage Tissue Repair
SALADINO, Silvia;GHERSI, Giulio
2014-01-01
Abstract
Biocompatibility analyses showed that formulated hydrogels were not toxic and didn’t induce apoptosis. Chondrocyte were alive but not proliferative, inflammation and immune responses were observed but under certain acceptability threshold. The results of this preliminary work suggest that the formulated Chitosan hydrogels are cyto-compatible and induce chondrocyte differentiation. The here tested synthesis process generated hydrogels, which are potentially useful for cartilage regenerative processes. Further mechanical characterizations are in progress.
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