HSP90 activities decline during ageing. Noteworthy, HSP90 mediated retrotransposon silencing seems to have a key role in the maintenance of genome integrity. Furthermore, inhibition of HSP90 activities lead to cell senescence and apoptosis. Original bioinformatics analyses and literature data will be discussed in the light of the potential involvement of HSP90 in ageing progression and ageing related diseases.
Arancio, W., Pizzolanti, G., Giordano, C. (2014). HSP90 in ageing progression and ageing related diseases. In Eurosymposium on Healthy Ageing.
HSP90 in ageing progression and ageing related diseases
ARANCIO, Walter;PIZZOLANTI, Giuseppe;GIORDANO, Carla
2014-01-01
Abstract
HSP90 activities decline during ageing. Noteworthy, HSP90 mediated retrotransposon silencing seems to have a key role in the maintenance of genome integrity. Furthermore, inhibition of HSP90 activities lead to cell senescence and apoptosis. Original bioinformatics analyses and literature data will be discussed in the light of the potential involvement of HSP90 in ageing progression and ageing related diseases.
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