By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensulfonic acid, new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine were obtained. The new synthesized compounds were tested preliminarly at 10 microM against five human cancer cell lines showing a range of inhibition of 20-62% against the most susceptible cell lines K562 and HCT116.
Maggio, B., Raffa, D., Raimondi, M.V., Plescia, F., Cusimano, M.G., Schillaci, D., et al. (2012). Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine. In Book of Abstracts of the 21th National Meeting on Medicinal Chemistry (pp. 102-102).
Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine
MAGGIO, Benedetta;RAFFA, Demetrio;RAIMONDI, Maria Valeria;PLESCIA, Fabiana;CUSIMANO, Maria Grazia;SCHILLACI, Domenico;CANCEMI, Gabriella;CASCIOFERRO, Stella Maria;DAIDONE, Giuseppe
2012-01-01
Abstract
By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensulfonic acid, new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine were obtained. The new synthesized compounds were tested preliminarly at 10 microM against five human cancer cell lines showing a range of inhibition of 20-62% against the most susceptible cell lines K562 and HCT116.
| File | Dimensione | Formato | |
|---|---|---|---|
|
NMMC_2012_P11.pdf
accesso aperto
Tipologia:
Versione Editoriale
Dimensione
118.53 kB
Formato
Adobe PDF
|
118.53 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
