Acetaldehyde (ACD), ethanol first metabolite, is rewarding in rodents and humans; it induces “place preference”, is self-administer directly in the VTA, orally in an operant/conflict paradigm and increases DA neurons’ firing. This research aims at investigating DA2-receptor role in the reinstatement of acetaldehyde operant-drinking behaviour, following induction, maintenance and abstinence in the rat. Male Wistar rats are trained to orally self-administer ACD solution (3.2% v/v) or water, in an operant chamber under a FR1. Afterwards animals undergo cyclic periods of deprivation and relapse to ACD. The effect ofD2-receptor activation by quinpirole (0.03mg/kg,i.p.) on operant ACD self-administration is tested during relapse sessions. Rats show a peak-and-drop drinking pattern that reaches regular and higher values in the last training days. Quinpirole administration produces lever press reduction in ACD group when compared to basal intake(p<0.001) and to vehicle (p<0.05;p<0.001), while when treatment is suspended, rats reinstate lever presses for ACD. ACD incentive properties involve dopamine neurotransmission: D2-receptor activation is able to reduce reinstatement of operant drinking behaviour for ACD, following periods of abstinence, probably acting at a pre-synaptic level, thus reducing DA release in mesolimbic areas. These findings further support ACD pivotal role in ethanol central effects.
Brancato, A., Marino, R., Plescia, F., Sutera, F., & Cannizzaro, C. (2013). Acetaldehyde operant self-administration in rats: focus on D2-receptor activation.. In Dopamine 2013.
|Autori:||Brancato, A.; Marino, R.; Plescia, F.; Sutera, F.; Cannizzaro, C.|
|Titolo:||Acetaldehyde operant self-administration in rats: focus on D2-receptor activation.|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di creazione:||2013-05-27|
|Nome del convegno:||Dopamine 2013|
|Data di pubblicazione:||2013|
|Numero di pagine:||515|
|Citazione:||Brancato, A., Marino, R., Plescia, F., Sutera, F., & Cannizzaro, C. (2013). Acetaldehyde operant self-administration in rats: focus on D2-receptor activation.. In Dopamine 2013.|
|Tipologia:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|
|Appare nelle tipologie:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|