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EnglishAcetaldehyde (ACD), ethanol first metabolite, is rewarding in rodents and humans; it induces “place preference”, is self-administer directly in the VTA, orally in an operant/conflict paradigm and increases DA neurons’ firing. This research aims at investigating DA2-receptor role in the reinstatement of acetaldehyde operant-drinking behaviour, following induction, maintenance and abstinence in the rat. Male Wistar rats are trained to orally self-administer ACD solution (3.2% v/v) or water, in an operant chamber under a FR1. Afterwards animals undergo cyclic periods of deprivation and relapse to ACD. The effect ofD2-receptor activation by quinpirole (0.03mg/kg,i.p.) on operant ACD self-administration is tested during relapse sessions. Rats show a peak-and-drop drinking pattern that reaches regular and higher values in the last training days. Quinpirole administration produces lever press reduction in ACD group when compared to basal intake(p<0.001) and to vehicle (p<0.05;p<0.001), while when treatment is suspended, rats reinstate lever presses for ACD. ACD incentive properties involve dopamine neurotransmission: D2-receptor activation is able to reduce reinstatement of operant drinking behaviour for ACD, following periods of abstinence, probably acting at a pre-synaptic level, thus reducing DA release in mesolimbic areas. These findings further support ACD pivotal role in ethanol central effects.
Brancato, A., Marino, R., Plescia, F., Sutera, F., & Cannizzaro, C. (2013). Acetaldehyde operant self-administration in rats: focus on D2-receptor activation.. In Dopamine 2013.
| Autori: | Brancato, A.; Marino, R.; Plescia, F.; Sutera, F.; Cannizzaro, C. | |
| Titolo: | Acetaldehyde operant self-administration in rats: focus on D2-receptor activation. | |
| Settore Scientifico Disciplinare: | Settore BIO/14 - Farmacologia | |
| Data di creazione: | 2013-05-27 | |
| Nome del convegno: | Dopamine 2013 | |
| Data di pubblicazione: | 2013 | |
| Numero di pagine: | 515 | |
| URL: | http://www.corsiecongressi.com/dopamine/final_program.asp | |
| Citazione: | Brancato, A., Marino, R., Plescia, F., Sutera, F., & Cannizzaro, C. (2013). Acetaldehyde operant self-administration in rats: focus on D2-receptor activation.. In Dopamine 2013. | |
| Tipologia: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) | |
| Appare nelle tipologie: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| finalProgram.pdf | Dopamine 2013 Program | N/A | Open Access Visualizza/Apri |
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