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EnglishNitric oxide (NO) acts as a messenger in the central nervous system; it affects the synaptic activity by modulating neurotransmitter release and/or receptor function. We previously observed that NO-active compounds modify the bioelectric activity of basal ganglia (BG) units. In this study, we applied microiontophoresis to extracellular in vivo recordings to investigate the effect of NO-active compounds on GABA-evoked responses in the globus pallidus (GP) of rats. The response to GABA release was tested on recorded GP neurons before and during the administration of S-nitroso-glutathione (SNOG, NO donor) and/or Nω-nitro-L-arginine methyl ester (L-NAME), inhibitor of nitric oxide synthase (NOS); furthermore, SNOG and L-NAME were tested at different ejection currents to highlight the possibility of a current-dependent effect in the nitrergic modulation. In general, during SNOG ejection the magnitude of GABA-evoked responses was reduced, whereas the administration of L-NAME produced the opposite effect. The results suggest that NO-active drugs modulate the response of GP neurons to GABA transmission; the effects induced by SNOG and L-NAME were strictly related to the ejection currents. Then, the modulation of GABAergic transmission by NO could represent a mechanism to finely regulate the GP neurons activity with important consequences on the overall BG function.
| Autori: | Carletti, F.; Ferraro, G.; Rizzo, V.; Friscia, S.; Sardo, P. |
| Titolo: | NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT |
| Settore Scientifico Disciplinare: | Settore BIO/09 - Fisiologia |
| Data di creazione: | 2012-04-20 |
| Nome del convegno: | XIV Congress of the Italian Society for Neuroscience - 1st Joint Meeting with the Israel Society for Neuroscience |
| Luogo del convegno: | Catania |
| Anno del convegno: | 19-22 Aprile 2012 |
| Data di pubblicazione: | 2012 |
| Numero di pagine: | 1 |
| Citazione: | Carletti, F., Ferraro, G., Rizzo, V., Friscia, S., & Sardo, P. (2012). NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT. In SINS 2012 - Program and abstract book (pp.285-285). |
| Tipologia: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |
| Appare nelle tipologie: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |
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