Nitric oxide (NO) acts as a messenger in the central nervous system; it affects the synaptic activity by modulating neurotransmitter release and/or receptor function. We previously observed that NO-active compounds modify the bioelectric activity of basal ganglia (BG) units. In this study, we applied microiontophoresis to extracellular in vivo recordings to investigate the effect of NO-active compounds on GABA-evoked responses in the globus pallidus (GP) of rats. The response to GABA release was tested on recorded GP neurons before and during the administration of S-nitroso-glutathione (SNOG, NO donor) and/or Nω-nitro-L-arginine methyl ester (L-NAME), inhibitor of nitric oxide synthase (NOS); furthermore, SNOG and L-NAME were tested at different ejection currents to highlight the possibility of a current-dependent effect in the nitrergic modulation. In general, during SNOG ejection the magnitude of GABA-evoked responses was reduced, whereas the administration of L-NAME produced the opposite effect. The results suggest that NO-active drugs modulate the response of GP neurons to GABA transmission; the effects induced by SNOG and L-NAME were strictly related to the ejection currents. Then, the modulation of GABAergic transmission by NO could represent a mechanism to finely regulate the GP neurons activity with important consequences on the overall BG function.
Carletti, F., Ferraro, G., Rizzo, V., Friscia, S., & Sardo, P. (2012). NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT. In SINS 2012 - Program and abstract book (pp.285-285).
|Autori:||Carletti, F.; Ferraro, G.; Rizzo, V.; Friscia, S.; Sardo, P.|
|Titolo:||NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
|Data di creazione:||2012-04-20|
|Nome del convegno:||XIV Congress of the Italian Society for Neuroscience - 1st Joint Meeting with the Israel Society for Neuroscience|
|Luogo del convegno:||Catania|
|Anno del convegno:||19-22 Aprile 2012|
|Data di pubblicazione:||2012|
|Numero di pagine:||1|
|Citazione:||Carletti, F., Ferraro, G., Rizzo, V., Friscia, S., & Sardo, P. (2012). NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT. In SINS 2012 - Program and abstract book (pp.285-285).|
|Tipologia:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|
|Appare nelle tipologie:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|