Nitric oxide (NO) acts as a messenger in the central nervous system; it affects the synaptic activity by modulating neurotransmitter release and/or receptor function. We previously observed that NO-active compounds modify the bioelectric activity of basal ganglia (BG) units. In this study, we applied microiontophoresis to extracellular in vivo recordings to investigate the effect of NO-active compounds on GABA-evoked responses in the globus pallidus (GP) of rats. The response to GABA release was tested on recorded GP neurons before and during the administration of S-nitroso-glutathione (SNOG, NO donor) and/or Nω-nitro-L-arginine methyl ester (L-NAME), inhibitor of nitric oxide synthase (NOS); furthermore, SNOG and L-NAME were tested at different ejection currents to highlight the possibility of a current-dependent effect in the nitrergic modulation. In general, during SNOG ejection the magnitude of GABA-evoked responses was reduced, whereas the administration of L-NAME produced the opposite effect. The results suggest that NO-active drugs modulate the response of GP neurons to GABA transmission; the effects induced by SNOG and L-NAME were strictly related to the ejection currents. Then, the modulation of GABAergic transmission by NO could represent a mechanism to finely regulate the GP neurons activity with important consequences on the overall BG function.

Carletti, F., Ferraro. G, Rizzo, V., Friscia. S, Sardo, P. (2012). NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT. In SINS 2012 - Program and abstract book (pp.285-285).

NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT

CARLETTI, Fabio;FERRARO, Giuseppe;RIZZO, Valerio;FRISCIA, Simonetta;SARDO, Pierangelo
2012-01-01

Abstract

Nitric oxide (NO) acts as a messenger in the central nervous system; it affects the synaptic activity by modulating neurotransmitter release and/or receptor function. We previously observed that NO-active compounds modify the bioelectric activity of basal ganglia (BG) units. In this study, we applied microiontophoresis to extracellular in vivo recordings to investigate the effect of NO-active compounds on GABA-evoked responses in the globus pallidus (GP) of rats. The response to GABA release was tested on recorded GP neurons before and during the administration of S-nitroso-glutathione (SNOG, NO donor) and/or Nω-nitro-L-arginine methyl ester (L-NAME), inhibitor of nitric oxide synthase (NOS); furthermore, SNOG and L-NAME were tested at different ejection currents to highlight the possibility of a current-dependent effect in the nitrergic modulation. In general, during SNOG ejection the magnitude of GABA-evoked responses was reduced, whereas the administration of L-NAME produced the opposite effect. The results suggest that NO-active drugs modulate the response of GP neurons to GABA transmission; the effects induced by SNOG and L-NAME were strictly related to the ejection currents. Then, the modulation of GABAergic transmission by NO could represent a mechanism to finely regulate the GP neurons activity with important consequences on the overall BG function.
Settore BIO/09 - Fisiologia
20-apr-2012
XIV Congress of the Italian Society for Neuroscience - 1st Joint Meeting with the Israel Society for Neuroscience
Catania
19-22 Aprile 2012
1
Carletti, F., Ferraro. G, Rizzo, V., Friscia. S, Sardo, P. (2012). NITRIC OXIDE-ACTIVE COMPOUNDS MODULATE IN VIVO GABA-EVOKED RESPONSES IN THE GLOBUS PALLIDUS OF RAT. In SINS 2012 - Program and abstract book (pp.285-285).
Proceedings (atti dei congressi)
Carletti, F; Ferraro. G; Rizzo, V; Friscia. S; Sardo, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/63344
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