Background: Experimental studies documented that endothelin-1 (ET-1) contributes to arterial stiffness and recently, in patients with chronic kidney diseases, it has been observed that selective endothelin-A receptor antagonism reduces arterial stiffness, in part independently of blood pressure lowering. Little is known about the relationships between ET-1 plasma levels and aortic distensibility in subjects with essential hypertension. Objective: The aim of our study was to analyse the relationships between plasma concentrations of ET-1 and carotid-femoral pulse wave velocity (c-f PWV), as an index of aortic stiffness, in a group of hypertensive patients without overt renal insufficiency [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 ]. Methods: We enrolled 216 pharmacologically untreated hypertensive patients (mean age 46 ± 10 years, males 62%). In all the subjects routine biochemical parameters and ET-1 plasma values, measured by a solid-phase specific sandwich enzyme-linked immunosorbent assay (Amersham kits), were obtained. Moreover, ambulatory blood pressure monitoring and measurement of c-f PWV, by a computerized automatic method (Complior), were performed. Results: The patients (n = 41) with elevated values of c-f PWV (> 12 m/sec) showed significantly higher ET-1 plasma levels than those of subjects with PWV < 12 m/sec (3.43 ± 0.43 vs 3.18 ± 0.42 pg/ml; p = 0.001 and p = 0.01, before and after adjustment for age and mean arterial pressure). A statistical significant correlation was found between ET-1 and c-f PWV in the whole study population (r = 0.29; p < 0.001). This association held even after adjustment for age, gender, mean arterial pressure, smoking, total cholesterol, glicaemia, waist circumference, HLD cholesterol, triglycerides and eGFR (beta = 0.17; p = 0.01). The correlation between ET-1 and aortic stiffness was equally significant in both sexes and stronger in diabetic patients (n = 17; r = 0.60) when compared to non diabetic subjects (r = 0.26). Conclusions: Our results seem to suggest that in hypertensive men and women, and especially in those with diabetes, an independent relationship exists between ET-1 plasma levels and aortic stiffness.

Mule’, G., Cottone, S., Cusimano, P., Palermo, A., Foraci, A.C., Costanzo, M., et al. (2011). PLASMA ENDOTHELIN-1 IS ASSOCIATED WITH AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION. In ABSTRACT BOOK OF THE 21st European Meeting on Hypertension and Cardiovascular Prevention (pp.e479-e479). Lippincott, Williams & Wilkins.

PLASMA ENDOTHELIN-1 IS ASSOCIATED WITH AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION

MULE', Giuseppe;COTTONE, Santina;CUSIMANO, Paola;PALERMO, Alessandro;FORACI, Anna Carola;COSTANZO, Miriam;NARDI, Emilio;CERASOLA, Giovanni
2011-01-01

Abstract

Background: Experimental studies documented that endothelin-1 (ET-1) contributes to arterial stiffness and recently, in patients with chronic kidney diseases, it has been observed that selective endothelin-A receptor antagonism reduces arterial stiffness, in part independently of blood pressure lowering. Little is known about the relationships between ET-1 plasma levels and aortic distensibility in subjects with essential hypertension. Objective: The aim of our study was to analyse the relationships between plasma concentrations of ET-1 and carotid-femoral pulse wave velocity (c-f PWV), as an index of aortic stiffness, in a group of hypertensive patients without overt renal insufficiency [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 ]. Methods: We enrolled 216 pharmacologically untreated hypertensive patients (mean age 46 ± 10 years, males 62%). In all the subjects routine biochemical parameters and ET-1 plasma values, measured by a solid-phase specific sandwich enzyme-linked immunosorbent assay (Amersham kits), were obtained. Moreover, ambulatory blood pressure monitoring and measurement of c-f PWV, by a computerized automatic method (Complior), were performed. Results: The patients (n = 41) with elevated values of c-f PWV (> 12 m/sec) showed significantly higher ET-1 plasma levels than those of subjects with PWV < 12 m/sec (3.43 ± 0.43 vs 3.18 ± 0.42 pg/ml; p = 0.001 and p = 0.01, before and after adjustment for age and mean arterial pressure). A statistical significant correlation was found between ET-1 and c-f PWV in the whole study population (r = 0.29; p < 0.001). This association held even after adjustment for age, gender, mean arterial pressure, smoking, total cholesterol, glicaemia, waist circumference, HLD cholesterol, triglycerides and eGFR (beta = 0.17; p = 0.01). The correlation between ET-1 and aortic stiffness was equally significant in both sexes and stronger in diabetic patients (n = 17; r = 0.60) when compared to non diabetic subjects (r = 0.26). Conclusions: Our results seem to suggest that in hypertensive men and women, and especially in those with diabetes, an independent relationship exists between ET-1 plasma levels and aortic stiffness.
Settore MED/09 - Medicina Interna
Settore MED/11 - Malattie Dell'Apparato Cardiovascolare
Settore MED/14 - Nefrologia
giu-2011
European Meeting on Hypertension and Cardiovascular Prevention
Milano
17-20 giugno
XXI
apr-2011
2011
1
Online
http://journals.lww.com/jhypertension/Documents/ESH%202011%20Poster%20Sessions.pdf
Abstract pubblicato su un Supplemento online di Journal of Hypertension interamente dedicato agli abstracts del Congresso
Mule’, G., Cottone, S., Cusimano, P., Palermo, A., Foraci, A.C., Costanzo, M., et al. (2011). PLASMA ENDOTHELIN-1 IS ASSOCIATED WITH AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION. In ABSTRACT BOOK OF THE 21st European Meeting on Hypertension and Cardiovascular Prevention (pp.e479-e479). Lippincott, Williams & Wilkins.
Proceedings (atti dei congressi)
Mule’, G; Cottone, S; Cusimano, P; Palermo, A; Foraci, AC; Costanzo, M; Nardi, E; Cerasola, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/55567
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