Improving fabrication protocols and design strategies, investigating on how scaffold architecture affects cell morphology, metabolism and phenotypic expression, predicting mechanical behaviors, have increasingly become crucial goals in the development of engineered tissue scaffolds. In the present study, an image-based analysis approach that provides an automatic tool to fully characterize engineered tissues fiber network topology was developed. The following micro architectural features are detected: fiber angle distribution, fiber connectivity, fiber overlap spatial density, fiber diameter. In order to demonstrate the potential of this approach Electrospun poly(ester urethane)urea (ES-PEUU) scaffolds were studied. Electrospun scaffolds were chosen for their recognized capability to recapitulate native soft tissue extra cellular matrix (ECM) morphology.

D'Amore, A., Stella, J., Wagner, W., Sacks, M. (2010). A Method to Extract the Complete Fiber Network Topology of Planar Fibrous Tissues and Scaffolds.. In Proceedings of the ASME 2010 Summer Bioengineering Conference (SBC2010).

A Method to Extract the Complete Fiber Network Topology of Planar Fibrous Tissues and Scaffolds.

D'AMORE, Antonio;
2010-01-01

Abstract

Improving fabrication protocols and design strategies, investigating on how scaffold architecture affects cell morphology, metabolism and phenotypic expression, predicting mechanical behaviors, have increasingly become crucial goals in the development of engineered tissue scaffolds. In the present study, an image-based analysis approach that provides an automatic tool to fully characterize engineered tissues fiber network topology was developed. The following micro architectural features are detected: fiber angle distribution, fiber connectivity, fiber overlap spatial density, fiber diameter. In order to demonstrate the potential of this approach Electrospun poly(ester urethane)urea (ES-PEUU) scaffolds were studied. Electrospun scaffolds were chosen for their recognized capability to recapitulate native soft tissue extra cellular matrix (ECM) morphology.
19-giu-2010
ASME 2010 Summer Bioengineering Conference (SBC2010)
Grande Beach Resort, Naples Florida, USA
June 16-19,
2
D'Amore, A., Stella, J., Wagner, W., Sacks, M. (2010). A Method to Extract the Complete Fiber Network Topology of Planar Fibrous Tissues and Scaffolds.. In Proceedings of the ASME 2010 Summer Bioengineering Conference (SBC2010).
Proceedings (atti dei congressi)
D'Amore, A;Stella,J, A;Wagner, W, R;Sacks, M, S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/51916
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