NEW GUIDED BONE REGENERATION PROCEDURE USING LEUKOCYTE AND PLATELET RICH FIBRIN (L PRF) IN ORAL SURGERY

Non-transfusional hemocomponents are autogenous products used in several surgical fields obtained by the centrifugation of a blood sample from a patient and able to promote hard and soft tissue regeneration, local haemostasis, and the acceleration of wound healing. The aim of this PhD thesis was the validation of an innovative protocol for the Guided Bone Regeneration (GBR) technique using second-generation autologous platelet concentrates, Leukocytes and Platelet-rich Fibrin (L-PRF), in post-extraction sockets of patients in need of dental avulsions and successive implant prosthetic rehabilitation, evaluating its ability to prevent alveolar bone resorption and promote bone regeneration. The secondary aim was the design and development of a multicomposite loaded with antimicrobic and antioxidant agents, to be applied wrapped in the L-PRF membrane, enhancing its regenerative properties. This project cohering with the National Operational Program (PON) “Research and Innovation” (R&I) 2014-2020 funding by the Italian Ministry of Education, University and Research, aimed to promote the research and the innovation of the country, with a particular interest on the Health Specialization Area.