Several studies have demonstrated the relationship between gonadotrophine serum levels and the apoptosis rate in germinal cells. In human, lower FSH serum levels are associated with reduced Sperm Standard Parameters in term of concentration, motility and morphology and higher sperm DNA fragmentation. Hypogonadotrope hypogonadism is a clinical condition associated with male infertility, characterized by low serum levels of gonadotrophins. In this pilot study we investigated the spermatozoa quality of 11 patients with development of hypogonadotrope hypogonadism urdergoing in vitro fertilization programs. Recombinant-FSH administered to improve the sperm parameters, apoptosis rate, aiming to increase the success of in vitro fertilization techniques. We found an effective procedure to highlight the correlation between spermatozoa morphology and DNA fragmentation, by TUNEL assay in situ. Spermatozoa integrity DNA influences reproductive potentiality and increases IVF outcome.
Bosco, L., Ruvolo, G., Chiarelli, R., Cittadini, E., & Roccheri, M. (2008). Evaluation of DNA damage in human spermatozoa: a sperm quality assay.. In 10° CONVEGNO FISV (pp.T.7 · P19-T.7 · P19).
Autori: | Bosco, L.; Ruvolo, G.; Chiarelli, R.; Cittadini, E.; Roccheri, M. | |
Titolo: | Evaluation of DNA damage in human spermatozoa: a sperm quality assay. | |
Settore Scientifico Disciplinare: | Settore BIO/06 - Anatomia Comparata E Citologia | |
Data di creazione: | 2008-09-25 | |
Nome del convegno: | 10° CONVEGNO FISV | |
Luogo del convegno: | RIVA DEL GARDA | |
Anno del convegno: | 24-27 SETTEMBRE 2008 | |
Numero del convegno: | 10 | |
Data di pubblicazione: | 2008 | |
Numero di pagine: | 1 | |
URL: | http://www.fisv.org/convegni/FISV2008/ShowAbstractOnline60e3.html?uai=139e42530630173417 | |
Citazione: | Bosco, L., Ruvolo, G., Chiarelli, R., Cittadini, E., & Roccheri, M. (2008). Evaluation of DNA damage in human spermatozoa: a sperm quality assay.. In 10° CONVEGNO FISV (pp.T.7 · P19-T.7 · P19). | |
Tipologia: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) | |
Appare nelle tipologie: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |
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