Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to imatinib. A central module is defined as a module of a GGM which contains genes that are defined differentially expressed.
Augugliaro, L., Mineo, A., Cammarata, G., Santoro, A. (2009). Genetic Network construction in CML gene expression profile data analysis. In Statistical Methods for the analysis of large data-sets (pp.323-326). PADOVA : CLEUP.
Genetic Network construction in CML gene expression profile data analysis
AUGUGLIARO, Luigi;MINEO, Angelo;
2009-01-01
Abstract
Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to imatinib. A central module is defined as a module of a GGM which contains genes that are defined differentially expressed.
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