The present invention concerns the preparation, the physical-chemical, technological and pharmaceutical characterization of Riluzole-loaded nanoparticle vectors. The chosen production technology permitted to obtain these systems in a reproducible way, with high yields and low costs. In particular, a novel formulation of Riluzole loaded into lipid nanoparticles was developed which is able to carry to the Central Nervous System a higher amount of drug in comparison with the free drug. In vivo results demonstrated that the administration on rats of these formulation permits to obtain a lower deposit of Riluzole in organs such as liver, spleen, heart and kidneys; the consequence is a reduction of side effects which actually are related with the administration of the free drug.
|Titolo:||NANOSTRUCTURED LIPID CARRIERS CONTAINING RILUZOLE AND PHARMACEUTICAL FORMULATIONS CONTAINING SAID PARTICLES|
|Data di pubblicazione:||2008|
|Citazione:||Bondi', M., Giammona, G., Craparo, E., & Drago, F. (2008)NANOSTRUCTURED LIPID CARRIERS CONTAINING RILUZOLE AND PHARMACEUTICAL FORMULATIONS CONTAINING SAID PARTICLES. . Brevetto No. WO2008/000448.|
|Appare nelle tipologie:||8.1 Brevetto|