An in vitro method able to modulate peripheral blood mononuclear cells of patients with auto-immune organ-specific diseases is described. The protocol makes auto-reactive lymphocytes tolerogenic through a process of re-education in recognition of self-antigen after co-culture with heterologous and/or autologous fibroblast limbal stem cells.
Giordano C, Coppola A, Pizzolanti G, Tomasello L (2017)In vitro cellular co-colture method to induce immunological tolerance. . Brevetto No. WO 2018/114469.
In vitro cellular co-colture method to induce immunological tolerance
Giordano CMembro del Collaboration Group
;Coppola AMembro del Collaboration Group
;Pizzolanti GMembro del Collaboration Group
;Tomasello LMembro del Collaboration Group
2017-01-01
Abstract
An in vitro method able to modulate peripheral blood mononuclear cells of patients with auto-immune organ-specific diseases is described. The protocol makes auto-reactive lymphocytes tolerogenic through a process of re-education in recognition of self-antigen after co-culture with heterologous and/or autologous fibroblast limbal stem cells.
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