A microphysiological tissue system (MPS) bioreactor has been developed to replicate in vitro the in vivo OC physiological conditions. The MPS allows separate control of the chondral and osseous environment while permitting communication between chondrocytes and osteoblasts across the OC junction, similar to the conditions of OC tissue in vivo. We have used here our MPS system to validate the TIPS -generated pore-gradient PLLA scaffold.
Gottardi, R., Conoscenti, G., Alexander, P., Manner, P., La Carrubba, V., Brucato, V., et al. (2016). A Poly-L-Lactide scaffold with continuous gradient pore size for osteochondral regeneration validated in a microphysiological tissue system bioreactor. In Orthopaedic Research Society 2016.
A Poly-L-Lactide scaffold with continuous gradient pore size for osteochondral regeneration validated in a microphysiological tissue system bioreactor
Conoscenti, Gioacchino;LA CARRUBBA, Vincenzo;BRUCATO, Valerio Maria Bartolo;
2016-01-01
Abstract
A microphysiological tissue system (MPS) bioreactor has been developed to replicate in vitro the in vivo OC physiological conditions. The MPS allows separate control of the chondral and osseous environment while permitting communication between chondrocytes and osteoblasts across the OC junction, similar to the conditions of OC tissue in vivo. We have used here our MPS system to validate the TIPS -generated pore-gradient PLLA scaffold.
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Gradient scaffold in bioreactor final.pdf
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ORS-2016-PROGRAM-BOOK_FOR_WEB.pdf
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