Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide ( CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.
LOMBARDO Y, DI STEFANO AB, IOVINO F, FRANCIPANE MG, SIRAGUSA M, TODARO M, et al. (2006). Thyroid stem cells: phenotypic properties, differentiation, potential and regulation by bone morphogenetic proteins. In 5th European Workshop on Cell Death (pp.64-64).
Thyroid stem cells: phenotypic properties, differentiation, potential and regulation by bone morphogenetic proteins
DI STEFANO, Anna Barbara;IOVINO, Flora;FRANCIPANE, Maria Giovanna;TODARO, Matilde;STASSI, Giorgio
2006-01-01
Abstract
Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide ( CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.
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