In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.
FIORENTINO FP, AGNESE V, CALÒ V, BRUNO L, AUGELLO C, CASCIO S, et al. (2007). Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.. In New Trends in Clinical Oncology - 9th National GOIM Congress 17-19 June 2007, Potenza, Italy (pp.vi188-vi188).
Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.
FIORENTINO, Francesco Paolo;AGNESE, Valentina;AUGELLO, Claudia;CASCIO, Sandra;BARBERA, Floriana;GREGORIO, Valter;CALCARA, Donatella;SCHIRO', Valentina;TERRASI, Marianna;FANALE, Daniele;SCOLARO, Laura;GRACEFFA, Giuseppa;DI GAUDIO, Francesca;BAZAN, Viviana;RUSSO, Antonio;AGNELLO, Giuseppe
2007-01-01
Abstract
In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.
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