The authors explored cross-sectional associations between MRI parameters (lesion metrics, brain volumes, magnetization transfer ratio histograms, and metabolite concentrations) and cognition in 61 patients who experienced clinically-isolated syndromes (CIS) 7 years earlier. IQ decline and poorer overall cognition were associated with T2 white-matter lesions, and slow informationprocessing with both T2 lesions and gray-matter atrophy. In a previous study of the same cohort, gray-matter atrophy measured shortly after CIS failed to predict development of cognitive impairment years later. Our findings suggest that gray-matter pathology, reflected by atrophy measurements, becomes increasingly important in determining cognition as MS progresses.
Penny, S.A., Summers, M.M., Swanton, J.K., Cipolotti, L., Miller, D.H., Ron, M.A. (2013). Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses. THE JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 25(2), 134-140 [10.1176/appi.neuropsych.11090218].
Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses.
CIPOLOTTI, Lisa;
2013-01-01
Abstract
The authors explored cross-sectional associations between MRI parameters (lesion metrics, brain volumes, magnetization transfer ratio histograms, and metabolite concentrations) and cognition in 61 patients who experienced clinically-isolated syndromes (CIS) 7 years earlier. IQ decline and poorer overall cognition were associated with T2 white-matter lesions, and slow informationprocessing with both T2 lesions and gray-matter atrophy. In a previous study of the same cohort, gray-matter atrophy measured shortly after CIS failed to predict development of cognitive impairment years later. Our findings suggest that gray-matter pathology, reflected by atrophy measurements, becomes increasingly important in determining cognition as MS progresses.File | Dimensione | Formato | |
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