3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.
Maggio, B., Cancemi, G., Raimondi, M.V., Plescia, F., Cascioferro, S.M., Cusimano, M.G., et al. (2014). Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives. In Atti del XXV Congresso Nazionale della Società Chimica Italiana. (pp.378-378).
Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives
MAGGIO, Benedetta;CANCEMI, Gabriella;RAIMONDI, Maria Valeria;PLESCIA, Fabiana;CASCIOFERRO, Stella Maria;CUSIMANO, Maria Grazia;LAURICELLA, Marianna;CARLISI, Daniela;DAIDONE, Giuseppe;RAFFA, Demetrio
2014-01-01
Abstract
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.
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