Abstract Background and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

MARIANI E, MONASTERO R, ERCOLANI S, MANGIALASCHE F, CAPUTO M, FELIZIANI FT, et al. (2007). Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 24(24), 448-456 [10.1159/000110653].

Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project

MONASTERO, Roberto
Writing – Review & Editing
;
VITALE, Domenico;
2007-01-01

Abstract

Abstract Background and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.
2007
Settore MED/26 - Neurologia
MARIANI E, MONASTERO R, ERCOLANI S, MANGIALASCHE F, CAPUTO M, FELIZIANI FT, et al. (2007). Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 24(24), 448-456 [10.1159/000110653].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/9798
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