Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting of several modifications that increase morbidity and mortality in elderly. Environment, genetic background, immune system, and intestinal microbiota play a fundamental role in immunosenescence. The development of a chronic, low-grade, inflammatory status, known as “inflamm-ageing,” is a typical aspect of immunosenescence mostly due to the pro-inflammatory cytokine production linked to the chronic antigenic load. Nutrition can act on ageing, immunity, and health in general. Unbalanced diet with an insufficient intake of micro- and macronutrient and vitamins is a major nutritional problem among elderly, resulting in a dramatic change in gut microbiota. Calorie restriction and long-term adherence to Mediterranean diet could prevent or manage agerelated diseases and immunosenescence.

Accardi, G., Balistreri, C.R., Caruso, C., Candore, G. (2014). Diet and Immunosenescence. In Immunology of aging (pp. 21-34). Springer-Verlag Berlin Heidelberg [DOI 10.1007/978-3-642-39495-9_21].

Diet and Immunosenescence

ACCARDI, Giulia;BALISTRERI, Carmela Rita;CARUSO, Calogero;CANDORE, Giuseppina
2014-01-01

Abstract

Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting of several modifications that increase morbidity and mortality in elderly. Environment, genetic background, immune system, and intestinal microbiota play a fundamental role in immunosenescence. The development of a chronic, low-grade, inflammatory status, known as “inflamm-ageing,” is a typical aspect of immunosenescence mostly due to the pro-inflammatory cytokine production linked to the chronic antigenic load. Nutrition can act on ageing, immunity, and health in general. Unbalanced diet with an insufficient intake of micro- and macronutrient and vitamins is a major nutritional problem among elderly, resulting in a dramatic change in gut microbiota. Calorie restriction and long-term adherence to Mediterranean diet could prevent or manage agerelated diseases and immunosenescence.
2014
Settore MED/05 - Patologia Clinica
Settore MED/04 - Patologia Generale
Accardi, G., Balistreri, C.R., Caruso, C., Candore, G. (2014). Diet and Immunosenescence. In Immunology of aging (pp. 21-34). Springer-Verlag Berlin Heidelberg [DOI 10.1007/978-3-642-39495-9_21].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/93523
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