Atherosclerosis (AS) is a chronic, progressive, multifactorial disease mostly affecting large and medium-sized elastic and muscular arteries. It has formerly been considered a bland lipid storage disease. Currently, multiple independent pathways of evidence suggest this pathological condition is a peculiar form of inflammation, triggered by cholesterol-rich lipoproteins and influenced both by environmental and genetic factors. The Human Genome Project opened up the opportunity to dissect complex human traits and to understand basic pathways of multifactorial diseases such as AS. Population-based association studies have emerged as powerful tools for examining genes with a role in common multifactorial diseases that have a strong environmental component. These association studies often estimate the risk of developing a certain disease in carriers and non-carriers of a particular genetic polymorphism. Dissecting out the influence of pro-inflammatory genes within the complex pathophysiology of AS and its complications will help to provide a more complete risk assessment and complement known classical cardiovascular risk factors. The detection of a risk profile will potentially allow both the early identification of individuals susceptible to disease and the possible discovery of potential targets for drug or lifestyle modification; i.e. it will open the door to personalized medicine.

Incalcaterra, E., Accardi, G., Balistreri, C.R., Caimi, G., Candore, G., Caruso, M., et al. (2013). Pro-inflammatory genetic markers of atherosclerosis. CURRENT ATHEROSCLEROSIS REPORTS, 15(6) [10.1007/s11883-013-0329-5].

Pro-inflammatory genetic markers of atherosclerosis

INCALCATERRA, Egle;ACCARDI, Giulia;BALISTRERI, Carmela Rita;CAIMI, Gregorio;CANDORE, Giuseppina;CARUSO, Marco;CARUSO, Calogero
2013-01-01

Abstract

Atherosclerosis (AS) is a chronic, progressive, multifactorial disease mostly affecting large and medium-sized elastic and muscular arteries. It has formerly been considered a bland lipid storage disease. Currently, multiple independent pathways of evidence suggest this pathological condition is a peculiar form of inflammation, triggered by cholesterol-rich lipoproteins and influenced both by environmental and genetic factors. The Human Genome Project opened up the opportunity to dissect complex human traits and to understand basic pathways of multifactorial diseases such as AS. Population-based association studies have emerged as powerful tools for examining genes with a role in common multifactorial diseases that have a strong environmental component. These association studies often estimate the risk of developing a certain disease in carriers and non-carriers of a particular genetic polymorphism. Dissecting out the influence of pro-inflammatory genes within the complex pathophysiology of AS and its complications will help to provide a more complete risk assessment and complement known classical cardiovascular risk factors. The detection of a risk profile will potentially allow both the early identification of individuals susceptible to disease and the possible discovery of potential targets for drug or lifestyle modification; i.e. it will open the door to personalized medicine.
2013
Settore MED/04 - Patologia Generale
Settore MED/05 - Patologia Clinica
Settore MED/09 - Medicina Interna
Incalcaterra, E., Accardi, G., Balistreri, C.R., Caimi, G., Candore, G., Caruso, M., et al. (2013). Pro-inflammatory genetic markers of atherosclerosis. CURRENT ATHEROSCLEROSIS REPORTS, 15(6) [10.1007/s11883-013-0329-5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/74727
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