Three new complexes of Ru(II), namely [RuCl2(Glun-N,O)2]Na2 (I; Glun = glucosaminate), [RuCl2(1- Tglu)(EtOH)2]Na (II; 1-Tglu = 1-thio-b-D-glucose) and [Ru2(EtOH)6(AL)Cl4] (III; AL=60-aminolactose) were prepared from the same Ru(II) precursor, [RuCl2(DMSO)4] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.
Fontana, G., Abbate, M., Casella, G., Pellerito, C., Longo, A., Ferrante, F. (2011). Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives. POLYHEDRON, 30, 1671-1679.
Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives
FONTANA, Gianfranco;CASELLA, Girolamo;PELLERITO, Claudia;FERRANTE, Francesco
2011-01-01
Abstract
Three new complexes of Ru(II), namely [RuCl2(Glun-N,O)2]Na2 (I; Glun = glucosaminate), [RuCl2(1- Tglu)(EtOH)2]Na (II; 1-Tglu = 1-thio-b-D-glucose) and [Ru2(EtOH)6(AL)Cl4] (III; AL=60-aminolactose) were prepared from the same Ru(II) precursor, [RuCl2(DMSO)4] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.
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