Ionizing radiation can be used as a drug sterilization technique, provided that the drug itself is not modified and that no toxic products are produced; moreover, if the irradiated product is a drug delivery system, the drug release characteristics must not be significantly altered by radiation. The aim of this work was to study the effects of sterilization by ionizing radiation on hydroxyethylcellulose/trehalose spherical micromatrices, containing the antibiotic vancomycin. Our experimental results showed that gamma-rays did not alter the chromophore groups of vancomycin (UV measurements), and did not modify the kinetic behavior of drug release from microspheres. Moreover, no significant changes in the shape and in the size distribution of microspheres were found after irradiation. The electron spin resonance (ESR) spectroscopy was proven to be a valid identification method of the executed radiation treatment, even after 5 years. The experimental results showed that the therapeutic application of the pharmacological system investigated was not compromised by irradiation, and that ESR spectroscopy can be used to distinguish irradiated from non-irradiated products.

BARTOLOTTA, A., D'OCA, M.C., CAMPISI, M., DE CARO, V., GIANDALIA, G., GIANNOLA, L.I., et al. (2005). Effects of gamma-irradiation on trehalose-hydroxyethylcellulose microspheres loaded with vancomycin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 59, 139-146 [10.1016/j.ejpb.2004.06.011].

Effects of gamma-irradiation on trehalose-hydroxyethylcellulose microspheres loaded with vancomycin

BARTOLOTTA, Antonio;D'OCA, Maria Cristina;DE CARO, Viviana;GIANDALIA, Giulia;GIANNOLA, Libero Italo;BRAI, Maria;CALDERARO, Elio Giuseppe
2005-01-01

Abstract

Ionizing radiation can be used as a drug sterilization technique, provided that the drug itself is not modified and that no toxic products are produced; moreover, if the irradiated product is a drug delivery system, the drug release characteristics must not be significantly altered by radiation. The aim of this work was to study the effects of sterilization by ionizing radiation on hydroxyethylcellulose/trehalose spherical micromatrices, containing the antibiotic vancomycin. Our experimental results showed that gamma-rays did not alter the chromophore groups of vancomycin (UV measurements), and did not modify the kinetic behavior of drug release from microspheres. Moreover, no significant changes in the shape and in the size distribution of microspheres were found after irradiation. The electron spin resonance (ESR) spectroscopy was proven to be a valid identification method of the executed radiation treatment, even after 5 years. The experimental results showed that the therapeutic application of the pharmacological system investigated was not compromised by irradiation, and that ESR spectroscopy can be used to distinguish irradiated from non-irradiated products.
2005
BARTOLOTTA, A., D'OCA, M.C., CAMPISI, M., DE CARO, V., GIANDALIA, G., GIANNOLA, L.I., et al. (2005). Effects of gamma-irradiation on trehalose-hydroxyethylcellulose microspheres loaded with vancomycin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 59, 139-146 [10.1016/j.ejpb.2004.06.011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/7369
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