Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. They offer unique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap active metal or mineral cores for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive and robust preparation methodologies is at the basis of the development of effective nanogel-based theragnostic devices. The design rules for mass fabrication of nanoscale hydrogel particles with the recourse to industrial-type accelerators is here discussed.

Dispenza, C., Sabatino, M.A., Grimaldi, N., Spadaro, G., Bulone, D., Bondì, M.L., et al. (2012). Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels. In E. Bardone, A. Brucato, T. Keshavarz (a cura di), CHEMICAL ENGINEERING TRANSACTIONS (pp. 229-234) [10.3303/CET1227039].

Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels

DISPENZA, Clelia;SABATINO, Maria Antonietta;GRIMALDI, Natascia;SPADARO, Giuseppe;ADAMO, Giorgia;RIGOGLIUSO, Salvatrice
2012-01-01

Abstract

Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. They offer unique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap active metal or mineral cores for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive and robust preparation methodologies is at the basis of the development of effective nanogel-based theragnostic devices. The design rules for mass fabrication of nanoscale hydrogel particles with the recourse to industrial-type accelerators is here discussed.
2012
Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie
Dispenza, C., Sabatino, M.A., Grimaldi, N., Spadaro, G., Bulone, D., Bondì, M.L., et al. (2012). Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels. In E. Bardone, A. Brucato, T. Keshavarz (a cura di), CHEMICAL ENGINEERING TRANSACTIONS (pp. 229-234) [10.3303/CET1227039].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/73661
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