Fetuin-A is a circulating inhibitor of ectopic calcification in vivo; it is decreased in patients with chronic kidney disease and correlates with glomerular filtration rate in patients with coronary artery disease. However, serum levels of Fetuin-A has not been described in elderly. Aim of the study was to evaluate Fetuin-A serum levels together with AHSG T256S genotype in a population of healthy elderly. Serum fetuin-A levels were determined by ELISA. T256S polymorphism of AHSG gene was determined by PCR-RFLP. Serum Fetuin-A was 0,38 ± 0,13 g/l in the group composed by 206 healthy centenarians. Moreover, subjects with at least one S allele had lower Fetuin-A levels (P<001). Interestingly, Fetuin-A was associated with increasing age (r=0.159; p=0.027; adjusted for sex). Fetuin-A increases with age in successful aging, suggesting a protective effect against vascular calcification exerted by Fetuin-A. Our results confirm T256S polymorphism as a genetic determinant of plasma fetuin-A levels.
BELLIA, C., MIGLIORISI, C., LO SASSO, B., MAIORANA, P., CARUSO, A., CIACCIO, M. (2011). Fetuin-A in elderly: effect of genotype on serum levels. In Medical Biotechnologies and Forensic Medicine Review (pp. 41-46).
Fetuin-A in elderly: effect of genotype on serum levels
BELLIA, Chiara;LO SASSO, Bruna;MAIORANA, Patrizia;CARUSO, Antonietta;CIACCIO, Marcello
2011-01-01
Abstract
Fetuin-A is a circulating inhibitor of ectopic calcification in vivo; it is decreased in patients with chronic kidney disease and correlates with glomerular filtration rate in patients with coronary artery disease. However, serum levels of Fetuin-A has not been described in elderly. Aim of the study was to evaluate Fetuin-A serum levels together with AHSG T256S genotype in a population of healthy elderly. Serum fetuin-A levels were determined by ELISA. T256S polymorphism of AHSG gene was determined by PCR-RFLP. Serum Fetuin-A was 0,38 ± 0,13 g/l in the group composed by 206 healthy centenarians. Moreover, subjects with at least one S allele had lower Fetuin-A levels (P<001). Interestingly, Fetuin-A was associated with increasing age (r=0.159; p=0.027; adjusted for sex). Fetuin-A increases with age in successful aging, suggesting a protective effect against vascular calcification exerted by Fetuin-A. Our results confirm T256S polymorphism as a genetic determinant of plasma fetuin-A levels.
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