D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.
TESORIERE, G., TESORIERE, L., VENTO, R., GIULIANO, M., CANTORO, G. (1984). The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells. EXPERIENTIA, 40(7), 705-707 [10.1007/BF01949733].
The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells
TESORIERE, Luisa;VENTO, Renza;GIULIANO, Michela;
1984-01-01
Abstract
D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.
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