The aim of the present methodological article was to assess whether a microstructure of hole-exploratory activity can be demonstrated in rats tested in the hole-board, an experimental assay widely used to study anxiety-related behaviors in rodents. Six never properly described hole exploratory behavioral components were identified: active-dip, static-dip, rapid-dip, circular-sniff, point-sniff and central-sniff. Results, assessed by means of descriptive and multivariate approaches, reveal a complex microstructural organization of these behavioral elements. The hypothesis of an important role of the relationships between point-sniff and head dipping activities, in anxiety-related hole exploratory behavior, is proposed. It is suggested that the microstructural analysis can evidence even subtle behavioral changes induced by manipulations of animal anxiety condition.
Casarrubea, M., Sorbera, F., Santangelo, A., Crescimanno, G. (2010). Microstructural assessment of rodent behavior in the hole-board experimental assay. In MB '10 Proceedings of the 7th International Conference on Methods and Techniques in Behavioral Research. Association for Computing Machinery, New York, NY - USA [10.1145/1931344.1931361].
Microstructural assessment of rodent behavior in the hole-board experimental assay
CASARRUBEA, Maurizio;SORBERA, Filippina;CRESCIMANNO, Giuseppe
2010-01-01
Abstract
The aim of the present methodological article was to assess whether a microstructure of hole-exploratory activity can be demonstrated in rats tested in the hole-board, an experimental assay widely used to study anxiety-related behaviors in rodents. Six never properly described hole exploratory behavioral components were identified: active-dip, static-dip, rapid-dip, circular-sniff, point-sniff and central-sniff. Results, assessed by means of descriptive and multivariate approaches, reveal a complex microstructural organization of these behavioral elements. The hypothesis of an important role of the relationships between point-sniff and head dipping activities, in anxiety-related hole exploratory behavior, is proposed. It is suggested that the microstructural analysis can evidence even subtle behavioral changes induced by manipulations of animal anxiety condition.
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