The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients share the HLA-DRB1*1501 susceptibility allele with affected living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.
BRASSAT D, SALEMI G, BARCELLOS LF, MCNEILL G, PROIA P, HAUSER SL, et al. (2005). The HLA locus and multiple sclerosis in Sicily. NEUROLOGY, 64(2), 361-363 [10.1212/01.WNL.0000149765.71212.0A].
The HLA locus and multiple sclerosis in Sicily
SALEMI, Giuseppe;PROIA, Patrizia;SAVETTIERI, Giovanni
2005-01-01
Abstract
The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients share the HLA-DRB1*1501 susceptibility allele with affected living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.
| File | Dimensione | Formato | |
|---|---|---|---|
|
The HLA locus and MS in Sicily Neurology 2005.pdf
Solo gestori archvio
Dimensione
59.64 kB
Formato
Adobe PDF
|
59.64 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
