Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 mu M, respectively. These two 1-analogues are promising lead compounds for further investigation.

ROSSELLI S, BRUNO M, MAGGIO A, BELLONE G, CHEN T H, BASTOW K F LEE K H (2007). Cytotoxic activity of some natural and synthetic kauranes. JOURNAL OF NATURAL PRODUCTS, 70(3), 347-352 [10.1021/np060504w].

Cytotoxic activity of some natural and synthetic kauranes

ROSSELLI, Sergio;BRUNO, Maurizio;MAGGIO, Antonella Maria;BELLONE, Gabriella;
2007-01-01

Abstract

Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 mu M, respectively. These two 1-analogues are promising lead compounds for further investigation.
2007
ROSSELLI S, BRUNO M, MAGGIO A, BELLONE G, CHEN T H, BASTOW K F LEE K H (2007). Cytotoxic activity of some natural and synthetic kauranes. JOURNAL OF NATURAL PRODUCTS, 70(3), 347-352 [10.1021/np060504w].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/5118
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