The objective of the study is to evaluate the effect of TNF inhibition on carotid thickness over a 2-year period. 144 women with RA diagnosed according to ACR criteria, without clinical evidence of cardiac and/or vascular disease were enrolled and compared with 78 matched controls. All patients received methotrexate (15–20 mg weekly) for 3 months. Responders (n = 79) continued to be treated with methotrexate, non-responders (n = 40) moved to methotrexate plus a TNF alpha antagonist. Echosonographic studies of carotids were obtained before and after 2-year follow-up. A significant decrease of ca-IMT was observed in anti-TNF-treated patients (P < 0.001); on the other hand, no significant variation of ca-IMT was observed after 2 years in MTX-treated patients. Our study indicates that anti-TNF blocking agents, but not methotrexate, are capable of reducing IMT of carotid arteries in female RA patients in a 2-year follow-up.

Ferrante, A., Giardina, A., Ciccia, F., Parrinello, G., Licata, G., Avellone, G., et al. (2009). Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL, 30, 193-198 [10.1007/s00296-009-0935-2].

Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis

FERRANTE, Angelo;GIARDINA, Annarita;CICCIA, Francesco;PARRINELLO, Gaspare;LICATA, Giuseppe;AVELLONE, Gino;IMPASTATO, Rosalia;TRIOLO, Giovanni
2009-01-01

Abstract

The objective of the study is to evaluate the effect of TNF inhibition on carotid thickness over a 2-year period. 144 women with RA diagnosed according to ACR criteria, without clinical evidence of cardiac and/or vascular disease were enrolled and compared with 78 matched controls. All patients received methotrexate (15–20 mg weekly) for 3 months. Responders (n = 79) continued to be treated with methotrexate, non-responders (n = 40) moved to methotrexate plus a TNF alpha antagonist. Echosonographic studies of carotids were obtained before and after 2-year follow-up. A significant decrease of ca-IMT was observed in anti-TNF-treated patients (P < 0.001); on the other hand, no significant variation of ca-IMT was observed after 2 years in MTX-treated patients. Our study indicates that anti-TNF blocking agents, but not methotrexate, are capable of reducing IMT of carotid arteries in female RA patients in a 2-year follow-up.
2009
Settore MED/16 - Reumatologia
Ferrante, A., Giardina, A., Ciccia, F., Parrinello, G., Licata, G., Avellone, G., et al. (2009). Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL, 30, 193-198 [10.1007/s00296-009-0935-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/49496
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