Abstract CD146+ bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment. In this study we used immunohistochemical analysis to investigate the contribution of CD146+ bone marrow osteoprogenitors to the stromal remodeling occurring in the different stages of primary myelofibrosis. We found that CD146+ cells sited at the abluminal side of the bone marrow vessels and branching among hematopoietic cells significantly increased in the advanced stages of primary myelofibrosis (p<0.001), paralleling the extent of fibrosis (r=0.916, p<0.0001) and the microvascular density (r=0.883, p<0.0001). Coherently with a mural cell function, such cells also displayed smooth-muscle actin expression. Our data providing evidence of CD146+ cell involvement in bone marrow stromal changes occurring in primary myelofibrosis are consistent with the capability of these cells to participate in fiber deposition, angiogenesis, and bone formation. They could also represent a rationale for new therapies targeting the bone marrow stroma in primary myelofibrosis. ©2009 Ferrata Storti Foundation.

Tripodo, C., Di Bernardo, A., Ternullo, M.P., Guarnotta, C., Porcasi, R., Ingrao, S., et al. (2009). CD146(+) bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis. HAEMATOLOGICA, 94(1), 127-130 [10.3324/haematol.13598].

CD146(+) bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis

TRIPODO, Claudio;DI BERNARDO, Andrea;TERNULLO, Maria Paola;GUARNOTTA, Carla;PORCASI, Rossana;INGRAO, Sabrina;FRANCO, Giovanni;FLORENA, Ada Maria
2009-01-01

Abstract

Abstract CD146+ bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment. In this study we used immunohistochemical analysis to investigate the contribution of CD146+ bone marrow osteoprogenitors to the stromal remodeling occurring in the different stages of primary myelofibrosis. We found that CD146+ cells sited at the abluminal side of the bone marrow vessels and branching among hematopoietic cells significantly increased in the advanced stages of primary myelofibrosis (p<0.001), paralleling the extent of fibrosis (r=0.916, p<0.0001) and the microvascular density (r=0.883, p<0.0001). Coherently with a mural cell function, such cells also displayed smooth-muscle actin expression. Our data providing evidence of CD146+ cell involvement in bone marrow stromal changes occurring in primary myelofibrosis are consistent with the capability of these cells to participate in fiber deposition, angiogenesis, and bone formation. They could also represent a rationale for new therapies targeting the bone marrow stroma in primary myelofibrosis. ©2009 Ferrata Storti Foundation.
2009
Tripodo, C., Di Bernardo, A., Ternullo, M.P., Guarnotta, C., Porcasi, R., Ingrao, S., et al. (2009). CD146(+) bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis. HAEMATOLOGICA, 94(1), 127-130 [10.3324/haematol.13598].
File in questo prodotto:
File Dimensione Formato  
127.full.pdf

accesso aperto

Dimensione 397.09 kB
Formato Adobe PDF
397.09 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/45048
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 29
social impact