1. 1. We have investigated the kinetics of inhibition of cathepsin D in heart, liver and skeletal muscle of CD-1 mice following administration of 25, 50, 100 and 200 mg/kg i.p. of pepstatin A, a specific inhibitor of this protease. 2. 2. In the liver, a significant inhibition of cathepsin D occurred up to at least 15 days, whereas, in heart and skeletal muscle, this inhibition lasted for a much shorter period of time. 3. 3. These results show that the recovery of enzyme activity to normal values is dose-dependent and that, at the same dose level, marked differences occur in the recovery of enzyme activity in these organ tissues, the liver being the most sensitive one. © 1988.

Leto G., Maria Tumminello F., Gebbia N., Rausa L. (1988). Kinetics of in vivo inhibition of tissue cathepsin d by pepstatin A. INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 20(9), 917-920 [10.1016/0020-711X(88)90175-9].

Kinetics of in vivo inhibition of tissue cathepsin d by pepstatin A

Leto G.
Conceptualization
;
Gebbia N.;Rausa L.
1988-01-01

Abstract

1. 1. We have investigated the kinetics of inhibition of cathepsin D in heart, liver and skeletal muscle of CD-1 mice following administration of 25, 50, 100 and 200 mg/kg i.p. of pepstatin A, a specific inhibitor of this protease. 2. 2. In the liver, a significant inhibition of cathepsin D occurred up to at least 15 days, whereas, in heart and skeletal muscle, this inhibition lasted for a much shorter period of time. 3. 3. These results show that the recovery of enzyme activity to normal values is dose-dependent and that, at the same dose level, marked differences occur in the recovery of enzyme activity in these organ tissues, the liver being the most sensitive one. © 1988.
1988
Leto G., Maria Tumminello F., Gebbia N., Rausa L. (1988). Kinetics of in vivo inhibition of tissue cathepsin d by pepstatin A. INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 20(9), 917-920 [10.1016/0020-711X(88)90175-9].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/434903
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