Type 1 diabetes is caused by the autoimmune destruction of pancreatic insulin-producing beta cells and most frequently occurs in genetically susceptible children. Due to beta cell loss, Type 1 diabetes is an ideal candidate for cell replacement therapy. Replacement could be achieved via whole pancreas or isolated islet transplantation, but, at present, feasibility of these procedures is severely limited by the shortage of donor pancreata. Stem cells, characterized by their high potential for self-renewal and the simultaneous ability to differentiate into a desired cytotype, theoretically represent a suitable and renewable source of surrogate beta cells. However, despite many promising results, several challenges still remain to be faced to turn the promise of cellular therapy for diabetes into a clinical reality.

CRISCIMANNA, A., TRUCCO M (2007). Stem cell replacement therapy in type 1 diabetes. THE ITALIAN JOURNAL OF PEDIATRICS, 33, 254-259.

Stem cell replacement therapy in type 1 diabetes

CRISCIMANNA, Angela;
2007-01-01

Abstract

Type 1 diabetes is caused by the autoimmune destruction of pancreatic insulin-producing beta cells and most frequently occurs in genetically susceptible children. Due to beta cell loss, Type 1 diabetes is an ideal candidate for cell replacement therapy. Replacement could be achieved via whole pancreas or isolated islet transplantation, but, at present, feasibility of these procedures is severely limited by the shortage of donor pancreata. Stem cells, characterized by their high potential for self-renewal and the simultaneous ability to differentiate into a desired cytotype, theoretically represent a suitable and renewable source of surrogate beta cells. However, despite many promising results, several challenges still remain to be faced to turn the promise of cellular therapy for diabetes into a clinical reality.
2007
Settore MED/13 - Endocrinologia
CRISCIMANNA, A., TRUCCO M (2007). Stem cell replacement therapy in type 1 diabetes. THE ITALIAN JOURNAL OF PEDIATRICS, 33, 254-259.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/41502
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact