Drug resistance is a major obstacle in antibiotic and antitumor chemotherapy. In response to the necessity to find new therapeutic strategies, plant secondary metabolites including essential oils (EOs) may represent one of the best sources. EOs in plants act as constitutive defenses against biotic and abiotic stress, and they play an important role in the pharmacology for their low toxicity, good pharmacokinetic and multitarget activity. In this context, natural products such as EOs are one of the most important sources of drugs used in pharmaceutical therapeutics. The aim of this paper was to identify the chemical composition of the essential oil of Alluaudia procera leaves, obtained by hydrodistillation and analysed by gas chromatography-mass spectrometry, and to verify its biological activities on acute myeloid leukemia cancer cell HL60 and its multidrugresistant variant HL60R and the Gram-positive Staphylococcus aureus exhibiting multi-antibiotic resistance. We speculate that cytotoxic and antibiotic effects observed in the tested resistant models may be due to the coordinate activities of forty compounds detected or to the C16 macrocyclic lactones which are the major ones (30%). Our data confirm the possibility of using EOs as therapeutic strategies in resistant models is due to the heterogeneous composition of the oils themselves.

Paola Poma, Manuela Labbozzetta, Pietro Zito, Rosa Alduina, Aro Vonjy Ramarosandratana, Maurizio Bruno, et al. (2019). Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models. MOLECULES, 24(16), 1-17 [10.3390/molecules24162871].

Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models

Paola Poma;Manuela Labbozzetta;Pietro Zito;Rosa Alduina;Maurizio Bruno;Sergio Rosselli
;
Maurizio Sajeva
;
Monica Notarbartolo
2019-08-07

Abstract

Drug resistance is a major obstacle in antibiotic and antitumor chemotherapy. In response to the necessity to find new therapeutic strategies, plant secondary metabolites including essential oils (EOs) may represent one of the best sources. EOs in plants act as constitutive defenses against biotic and abiotic stress, and they play an important role in the pharmacology for their low toxicity, good pharmacokinetic and multitarget activity. In this context, natural products such as EOs are one of the most important sources of drugs used in pharmaceutical therapeutics. The aim of this paper was to identify the chemical composition of the essential oil of Alluaudia procera leaves, obtained by hydrodistillation and analysed by gas chromatography-mass spectrometry, and to verify its biological activities on acute myeloid leukemia cancer cell HL60 and its multidrugresistant variant HL60R and the Gram-positive Staphylococcus aureus exhibiting multi-antibiotic resistance. We speculate that cytotoxic and antibiotic effects observed in the tested resistant models may be due to the coordinate activities of forty compounds detected or to the C16 macrocyclic lactones which are the major ones (30%). Our data confirm the possibility of using EOs as therapeutic strategies in resistant models is due to the heterogeneous composition of the oils themselves.
7-ago-2019
Settore BIO/03 - Botanica Ambientale E Applicata
Settore BIO/15 - Biologia Farmaceutica
Settore BIO/14 - Farmacologia
Settore CHIM/06 - Chimica Organica
Settore BIO/19 - Microbiologia Generale
Paola Poma, Manuela Labbozzetta, Pietro Zito, Rosa Alduina, Aro Vonjy Ramarosandratana, Maurizio Bruno, et al. (2019). Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models. MOLECULES, 24(16), 1-17 [10.3390/molecules24162871].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/366850
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