Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.

Spatari G., Fenga C., Minciullo P.L., Di Pasquale G., Cacciola A., Ventura-Spagnolo E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62 [10.1155/MI.2005.60].

Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents

Ventura-Spagnolo E.
Membro del Collaboration Group
;
2005-01-01

Abstract

Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer. © 2005 Hindawi Publishing Corporation.
2005
Settore MED/43 - Medicina Legale
Spatari G., Fenga C., Minciullo P.L., Di Pasquale G., Cacciola A., Ventura-Spagnolo E., et al. (2005). Modification of interleukin-15 serum levels in workers exposed to chemotherapeutic agents. MEDIATORS OF INFLAMMATION, 2005(1), 60-62 [10.1155/MI.2005.60].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/363609
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