Research on bicuspid aortic valve disease (BAV) and related complications has grown in an exponential manner in the last decades. However, the current knowledge of the mechanisms underlying the development of this disease is still limited, since all clinical and surgical studies on BAV mainly focused their objects on its major vascular complications, such as ascending aortic aneurysms and dissection. It is now clear that a better understanding of the pivotal molecular and cellular pathophysiological aspects of bicuspid valve aortopathy, including natural history, phenotypic expression, histology, cellular mechanisms and pathways, is critical for improving its clinical management. This changing paradigm has clearly emerged in the recently released American Association for Thoracic Surgery (AATS) consensus guidelines focusing on bicuspid aortic valve-related aortopathy, which covered all major aspects of BAV

Balistreri C.R., Cavarretta E., Sciarretta S., Frati G. (2019). Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 133, 113-114 [10.1016/j.yjmcc.2019.06.004].

Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity

Balistreri C. R.
Supervision
;
2019-01-01

Abstract

Research on bicuspid aortic valve disease (BAV) and related complications has grown in an exponential manner in the last decades. However, the current knowledge of the mechanisms underlying the development of this disease is still limited, since all clinical and surgical studies on BAV mainly focused their objects on its major vascular complications, such as ascending aortic aneurysms and dissection. It is now clear that a better understanding of the pivotal molecular and cellular pathophysiological aspects of bicuspid valve aortopathy, including natural history, phenotypic expression, histology, cellular mechanisms and pathways, is critical for improving its clinical management. This changing paradigm has clearly emerged in the recently released American Association for Thoracic Surgery (AATS) consensus guidelines focusing on bicuspid aortic valve-related aortopathy, which covered all major aspects of BAV
2019
Settore MED/05 - Patologia Clinica
Balistreri C.R., Cavarretta E., Sciarretta S., Frati G. (2019). Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 133, 113-114 [10.1016/j.yjmcc.2019.06.004].
File in questo prodotto:
File Dimensione Formato  
JMCC 2019.pdf, 2.pdf

Solo gestori archvio

Descrizione: pdf paper pubblicato
Tipologia: Versione Editoriale
Dimensione 349.23 kB
Formato Adobe PDF
349.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/361571
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact