A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.
BARRAJA P, DIANA P, LAURIA A, MONTALBANO A, ALMERICO AM, DATTOLO G, et al. (2004). Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles. ANTICANCER RESEARCH, 24(6), 3775-3780.
Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles
BARRAJA, Paola;DIANA, Patrizia;LAURIA, Antonino;MONTALBANO, Alessandra;ALMERICO, Anna Maria;DATTOLO, Gaetano;CIRRINCIONE, Girolamo
2004-01-01
Abstract
A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.
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