Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. The aim of this review was to provide an updated and comprehensive report of the global spread of C. auris, focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies.

Andrea Cortegiani, G.M. (2018). Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris. JOURNAL OF INTENSIVE CARE, 6(1), 1-13 [10.1186/s40560-018-0342-4].

Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris

Cortegiani, Andrea
;
MISSERI, Giovanni;Fasciana, Teresa Maria Assunta;Anna Giammanco;Antonino Giarratano;
2018-01-01

Abstract

Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. The aim of this review was to provide an updated and comprehensive report of the global spread of C. auris, focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies.
2018
Settore MED/07 - Microbiologia E Microbiologia Clinica
Settore MED/41 - Anestesiologia
Andrea Cortegiani, G.M. (2018). Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris. JOURNAL OF INTENSIVE CARE, 6(1), 1-13 [10.1186/s40560-018-0342-4].
File in questo prodotto:
File Dimensione Formato  
C.auris R.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Versione Editoriale
Dimensione 1.82 MB
Formato Adobe PDF
1.82 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/314731
Citazioni
  • ???jsp.display-item.citation.pmc??? 109
  • Scopus 184
  • ???jsp.display-item.citation.isi??? 160
social impact