The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2′-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.
RAIMONDI, M.V., CASCIOFERRO, S., SCHILLACI, D., PETRUSO, S. (2006). Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 41(12), 1439-1445 [10.1016/j.ejmech.2006.07.009].
Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin
RAIMONDI, Maria Valeria;CASCIOFERRO, Stella Maria;SCHILLACI, Domenico;PETRUSO, Salvatore
2006-01-01
Abstract
The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2′-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.
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