The effects induced on the discharge of subthalamic spontaneously active neurons by inhibiting the enzyme nitric oxide synthase was studied in two groups of urethane-anesthetized rats. In the first group of animals (n = 10), the activity of subthalamic single units was recorded before and after the systemic administration of 7-nitro-indazole (7-NI, 50 mg/kg i.p.), a selective inhibitor of neuronal nitric oxide synthase. In the second group of rats (n = 15), N-nitro-l-arginine methyl ester (L-NAME), another inhibitor of nitric oxide synthase, was iontophoretically administered while performing single unit extracellular recordings. The activity of most tested spontaneously discharging neurons (8/10) was influenced by 7-NI administration, which always caused a statistically significant decrease in the firing rate of the responsive cells. In contrast, the iontophoretic administration of L-NAME, although influencing many cells (24/32), did not have univocal effects: in fact, 18 cells were inhibited while 6 neurons were excited in a statistically significant manner.We hypothesize that nitric oxide neurotransmission could exert a tonic modulatory influence upon spontaneously discharging subthalamic neurons, with a prevalent excitatory effect.

SARDO P, FERRARO G, CARLETTI F, D'AGOSTINO S, LA GRUTTA V (2006). The discharge of subthalamic neurons is modulated by inhibiting the nitric oxide synthase in the rat . NEUROSCIENCE LETTERS, 396 (3), 252-256 [10.1016/j.neulet.2005.11.054].

The discharge of subthalamic neurons is modulated by inhibiting the nitric oxide synthase in the rat .

SARDO, Pierangelo;FERRARO, Giuseppe;CARLETTI, Fabio;D'AGOSTINO, Stefania;LA GRUTTA, Vittorio
2006-01-01

Abstract

The effects induced on the discharge of subthalamic spontaneously active neurons by inhibiting the enzyme nitric oxide synthase was studied in two groups of urethane-anesthetized rats. In the first group of animals (n = 10), the activity of subthalamic single units was recorded before and after the systemic administration of 7-nitro-indazole (7-NI, 50 mg/kg i.p.), a selective inhibitor of neuronal nitric oxide synthase. In the second group of rats (n = 15), N-nitro-l-arginine methyl ester (L-NAME), another inhibitor of nitric oxide synthase, was iontophoretically administered while performing single unit extracellular recordings. The activity of most tested spontaneously discharging neurons (8/10) was influenced by 7-NI administration, which always caused a statistically significant decrease in the firing rate of the responsive cells. In contrast, the iontophoretic administration of L-NAME, although influencing many cells (24/32), did not have univocal effects: in fact, 18 cells were inhibited while 6 neurons were excited in a statistically significant manner.We hypothesize that nitric oxide neurotransmission could exert a tonic modulatory influence upon spontaneously discharging subthalamic neurons, with a prevalent excitatory effect.
2006
Settore BIO/09 - Fisiologia
SARDO P, FERRARO G, CARLETTI F, D'AGOSTINO S, LA GRUTTA V (2006). The discharge of subthalamic neurons is modulated by inhibiting the nitric oxide synthase in the rat . NEUROSCIENCE LETTERS, 396 (3), 252-256 [10.1016/j.neulet.2005.11.054].
File in questo prodotto:
File Dimensione Formato  
Neuroscience Letters 396(2006) 252-256.pdf

Solo gestori archvio

Dimensione 166.71 kB
Formato Adobe PDF
166.71 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/26240
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 11
social impact