A comparative study on the ability of various polymers to interact with a biomembrane model was carried out by differential scanning calorimetry (DSC). The investigated samples were a water soluble polymer, the α,β-polyaspartylhydrazide (PAHy) and its derivatives containing polyethylene glycol (PEG2000) (sample PAHy–PEG2000), or hexadecylamine (C16) (sample PAHy–C16) or both compounds (sample PAHy–PEG2000–C16). Some samples are able to arrange themselves as micellar structures and to interact potentially with the membrane surface so as to favor the release of the drug near the target membrane and consequently to improve drug adsorption processes. First, the interaction of all polymers with a biomembrane model made of multilamellar vesicles of mixed (80:20, mol:mol) dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidic acid (DMPA), has been studied (pH 7.4), then the interaction of Ketoprofen (KPF) as free drug or released from PAHy–C16 micelles with the same biomembrane model has been investigated. Differential scanning calorimetry appears to be a suitable technique to follow the interaction of all prepared samples as well as the transfer kinetics of a drug from PAHy–C16 micelles to a biomembrane model. The drug release kinetics, from PAHy–C16 micelles, was compared with the transfer of free drug (after dissolution from a solid form) by evaluating their effects on the thermotropic behavior of DMPC/DMPA multilamellar vesicles.

CASTELLI F, MESSINA C, MARTINETTI E, LICCIARDI M, CRAPARO EF, PITARRESI G (2004). Influence of functionalization on interaction and drug release from alpha,beta-polyaspartylhydrazide derivatives to a biomembrane model: evaluation by differential scanning calorimetry technique. THERMOCHIMICA ACTA, 423(1-2), 19-28 [10.1016/j.tca.2004.04.013].

Influence of functionalization on interaction and drug release from alpha,beta-polyaspartylhydrazide derivatives to a biomembrane model: evaluation by differential scanning calorimetry technique

CASTELLI, Francesco;LICCIARDI, Mariano;CRAPARO, Emanuela Fabiola;PITARRESI, Giovanna
2004-01-01

Abstract

A comparative study on the ability of various polymers to interact with a biomembrane model was carried out by differential scanning calorimetry (DSC). The investigated samples were a water soluble polymer, the α,β-polyaspartylhydrazide (PAHy) and its derivatives containing polyethylene glycol (PEG2000) (sample PAHy–PEG2000), or hexadecylamine (C16) (sample PAHy–C16) or both compounds (sample PAHy–PEG2000–C16). Some samples are able to arrange themselves as micellar structures and to interact potentially with the membrane surface so as to favor the release of the drug near the target membrane and consequently to improve drug adsorption processes. First, the interaction of all polymers with a biomembrane model made of multilamellar vesicles of mixed (80:20, mol:mol) dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidic acid (DMPA), has been studied (pH 7.4), then the interaction of Ketoprofen (KPF) as free drug or released from PAHy–C16 micelles with the same biomembrane model has been investigated. Differential scanning calorimetry appears to be a suitable technique to follow the interaction of all prepared samples as well as the transfer kinetics of a drug from PAHy–C16 micelles to a biomembrane model. The drug release kinetics, from PAHy–C16 micelles, was compared with the transfer of free drug (after dissolution from a solid form) by evaluating their effects on the thermotropic behavior of DMPC/DMPA multilamellar vesicles.
2004
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
CASTELLI F, MESSINA C, MARTINETTI E, LICCIARDI M, CRAPARO EF, PITARRESI G (2004). Influence of functionalization on interaction and drug release from alpha,beta-polyaspartylhydrazide derivatives to a biomembrane model: evaluation by differential scanning calorimetry technique. THERMOCHIMICA ACTA, 423(1-2), 19-28 [10.1016/j.tca.2004.04.013].
File in questo prodotto:
File Dimensione Formato  
thermochimicaacta2004.pdf

Solo gestori archvio

Descrizione: Articolo
Dimensione 704.09 kB
Formato Adobe PDF
704.09 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/26162
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
social impact